Evidence map›Paper›PMID 41430567›Full record

ReviewCellular & molecular biology letters2025

Beyond the mutations: spatiotemporal regulation of CFTR by cAMP and calcium signaling in epithelial physiology and cystic fibrosis.

Arpad Varga, Aletta Kiss, Tim Crul, Tamara Madácsy, Petra Pallagi, József Maléth

Abstract readReview
In one paragraph

Review in Cellular & molecular biology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Epigenetic regulation and chromatin organization in cystic fibrosis airways.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arpad VargaFirst Department of Medicine, University of Szeged, Szeged, 6720, Hungary.
Aletta KissFirst Department of Medicine, University of Szeged, Szeged, 6720, Hungary.
Tim CrulFirst Department of Medicine, University of Szeged, Szeged, 6720, Hungary.
Tamara MadácsyFirst Department of Medicine, University of Szeged, Szeged, 6720, Hungary.
Petra PallagiFirst Department of Medicine, University of Szeged, Szeged, 6720, Hungary.
József MaléthFirst Department of Medicine, University of Szeged, Szeged, 6720, Hungary. jozsefmaleth1@gmail.com.ORCID http://orcid.org/0000-0001-5768-3090

Funding

Magyar Tudományos Akadémia (LP2017-18/2017)Szent-Györgyi Albert Orvostudományi Kar, Szegedi Tudományegyetem (IV-3264-62-1/1/2024.SZAOK)
6 · The paper itself

Abstract

Cystic fibrosis (CF) is a life-shortening monogenic disease caused by mutations in the CFTR gene, but the functional expression of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl

Indexed as

Calcium SignalingCyclic AMPCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsMutationAnimalsCyclic AMP-Dependent Protein KinasesHumansCFTR protein, humanCyclic AMPCyclic AMP-Dependent Protein KinasesCystic Fibrosis Transmembrane Conductance RegulatorCalcium signalingcAMP signalingCFTR regulationCystic fibrosis

Identifiers

PMID41430567
PMCPMC12837602

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.