Evidence map›Paper›PMID 41430436›Full record

ArticleNature2026

NAC controls nascent chain fate through tunnel sensing and chaperone action.

Jae Ho Lee, Laurenz Rabl, Martin Gamerdinger, Vaishali Goyal, Katrin Michaela Khakzar, Natalia Moreira Barbosa, Juliana Abramovich, Fabian Morales-Polanco, Ann-Kathrin Köhler, Ekaterina Samatova and 3 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Jae Ho LeeDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-8663-3209
Laurenz RablDepartment of Biology, Molecular Microbiology, University of Konstanz, Konstanz, Germany.ORCID 0000-0002-3736-9800
Martin GamerdingerDepartment of Biology, Molecular Microbiology, University of Konstanz, Konstanz, Germany.ORCID 0000-0003-1483-8181
Vaishali GoyalDepartment of Physical Biochemistry, Max Planck Institute for Multidisciplinary Sciences, Goettingen, Germany.ORCID 0009-0006-1252-230X
Katrin Michaela KhakzarDepartment of Biology, Molecular Microbiology, University of Konstanz, Konstanz, Germany.
Natalia Moreira BarbosaDepartment of Biology, Stanford University, Stanford, CA, USA.
Juliana AbramovichDepartment of Biology, Stanford University, Stanford, CA, USA.
Fabian Morales-PolancoDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-7695-3081
Ann-Kathrin KöhlerDepartment of Biology, Molecular Microbiology, University of Konstanz, Konstanz, Germany.ORCID 0009-0007-6155-4719
Ekaterina SamatovaDepartment of Physical Biochemistry, Max Planck Institute for Multidisciplinary Sciences, Goettingen, Germany.
Marina V RodninaDepartment of Physical Biochemistry, Max Planck Institute for Multidisciplinary Sciences, Goettingen, Germany. rodnina@mpinat.mpg.de.ORCID 0000-0003-0105-3879
Elke DeuerlingDepartment of Biology, Molecular Microbiology, University of Konstanz, Konstanz, Germany. elke.deuerling@uni-konstanz.de.ORCID 0000-0002-8905-0260
Judith FrydmanDepartment of Biology, Stanford University, Stanford, CA, USA. jfrydman@stanford.edu.ORCID 0000-0003-2302-6943

Funding

PROTEIN FOLDING IN THE EUKARYOTIC CYTOSOLR01GM056433 · NIGMS · STANFORD UNIVERSITY · PI Judith Frydman · 1997 to 2026
$5.0M
NIGMS NIH HHS R01 GM056433
6 · The paper itself

Abstract

The nascent polypeptide-associated complex (NAC) is a conserved ribosome-bound factor with essential yet incompletely understood roles in protein biogenesis

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsMolecular ChaperonesProtein BiosynthesisAnimalsEndoplasmic ReticulumKineticsPeptide Chain Elongation, TranslationalProtein BindingProtein FoldingProteomeRibosomesCaenorhabditis elegans ProteinsMolecular Chaperonesnascent-polypeptide-associated complexProteome

Identifiers

PMID41430436
PMCPMC13043293

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.