Evidence map›Paper›PMID 41430390›Full record

Trial reportEye (London, England)2026

Metabolomic characteristics of aqueous humor in young myopia patients without fundus complications.

Mengjun Fu, Xiaobo Zhang, Xiangyuan Song, Yijie Xu, Jingjing Zhao, Jiahao Wang, Yongchao Wang, Kunning Wang, Qihu Tong, Haorun Zhang and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Mengjun Fu *State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xiaobo Zhang *State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.ORCID 0000-0002-7573-9200
Xiangyuan SongState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yijie XuState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jingjing ZhaoWeifang Eye Institute, National key clinical specialty, Weifang Eye Hospital, Zhengda Guangming Eye Group, Weifang, China.
Jiahao WangWeifang Eye Institute, National key clinical specialty, Weifang Eye Hospital, Zhengda Guangming Eye Group, Weifang, China.
Yongchao WangWeifang Eye Institute, National key clinical specialty, Weifang Eye Hospital, Zhengda Guangming Eye Group, Weifang, China.
Kunning WangWeifang Eye Institute, National key clinical specialty, Weifang Eye Hospital, Zhengda Guangming Eye Group, Weifang, China.
Qihu TongDepartment of Ophthalmology, Yinzhou People's Hospital, Medical School of Ningbo University, Ningbo, China.
Haorun ZhangWeifang Eye Institute, National key clinical specialty, Weifang Eye Hospital, Zhengda Guangming Eye Group, Weifang, China. haorunzhang2021@163.com.
Zai-Long ChiState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. zailong.chi@eye.ac.cn.ORCID 0000-0002-3617-6425

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo explore the potential mechanisms of myopia by detecting metabolites in the aqueous humour (AH) of young patients with myopia without fundus complications.

methodsRandomised controlled trials (RCTs). A total of 65 AH samples (65 eyes) were collected in Weifang Eye Hospital. Untargeted metabolomics was conducted via liquid chromatography‒tandem mass spectrometry (LC‒MS/MS). Receiver operating characteristic (ROC) curves were generated.

resultsPatients were divided into three groups according to axial length (AL). There were 21 patients (21 eyes) in the moderate-myopia (MM) group (24.00 mm < AL ≤ 26.00 mm), 24 patients (24 eyes) in the high-myopia (HM) group (26.00 mm < AL ≤ 28.00 mm), and 20 patients (20 eyes) in the ultrahigh-myopia (UHM) group (AL > 28.00 mm). A total of 2203 metabolites were detected in the AH samples, and there were 62 shared differentially abundant metabolites among the three groups. KEGG pathways among the three groups included sphingolipid metabolism, lipid and atherosclerosis, and the pentose phosphate pathway (PPP). The key metabolites DL-glutamine, phytosphingosine, D-erythrose 4-phosphate, and pyridoxine phosphate exhibited the strongest correlations with AL (all P values were <0.0001). In the ROC analysis, DL-glutamine, phytosphingosine, and D-erythrose 4-phosphate were good biomarkers for MM. Pyridoxine phosphate was a potential biomarker for UHM.

conclusionsAbnormal sphingolipid metabolism was closely related to myopia. Changes in phytosphingosine levels in the AH among various AL groups may serve as early warning signs of retinal changes. These metabolic pathways and metabolites could serve as intervention targets for myopia management in the future.

Indexed as

Aqueous HumorMetabolomeMetabolomicsMyopiaAdolescentAdultAxial Length, EyeBiomarkersChromatography, LiquidFemaleHumansMaleROC CurveTandem Mass SpectrometryYoung AdultBiomarkers

Identifiers

PMID41430390
PMCPMC12881359

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.