ArticleJournal of nanobiotechnology2025
YTHDF1 transcriptionally activated by TCF4 suppresses osteoblast ferroptosis in titanium nanoparticle-induced osteolysis by accelerating GPX4 and SLC7A11 translation.
Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic review of machine learning approaches for predicting sickle cell crisis and mortality risk at the climate-health nexus.BMC medical informatics and decision making · 2026Pooled it
- Efficacy and safety of different curcumin formulations in osteoarthritis: an umbrella review of systematic reviews.Frontiers in medicine · 2026Pooled it
- Global burden of pain in malignant bone tumors: a meta-analysis of severity and health outcomes.Frontiers in oncology · 2026Pooled it
- Bioinspired 0D mitochondrial bioenergetic actuators rewire cartilage progenitor cell metabolism for osteoarthritis remission.Bioactive materials · 2026Article
- Promoting Bone Health in Layer Chickens from the Perspective of Mitochondrial Energy Metabolism in Osteoclasts.Animals : an open access journal from MDPI · 2026Review
- USP43-mediated deubiquitination of SLC7A11 protects against LPS-induced acute lung injury by inhibiting ferroptosis.Clinical and translational medicine · 2026Article
- Bioengineering Strategies to Address Key Bottlenecks in Ferroptosis-Based Cancer Therapy: A Critical Review.International journal of nanomedicine · 2026Review
- Targeting glutathione peroxidase 4 in ferroptosis: from immune regulation to pharmacological development and translational applications.Frontiers in pharmacology · 2026Review
- Ferroptosis-neuroinflammation interplay: mechanistic pathways and therapeutic opportunities in central nervous system disorders.Frontiers in aging neuroscience · 2026Review
- Ferroptosis in orthopedic implant integration after oncologic surgery.Frontiers in oncology · 2026Review
- Apigenin Upregulates Regulatory B Cells, Suppresses Class Switch Recombination, and Restores Immune Homeostasis to Treat Autoimmune Arthritis and Sepsis.Drug design, development and therapy · 2026Article
- Sepsis in Autoimmune Rheumatic Diseases: Risk Factors, Pathophysiology, and Outcomes.Risk management and healthcare policy · 2026Review
- Tumor-nerve crosstalk: peripheral mechanisms mediating bone tumor progression and cancer-induced bone pain.Frontiers in oncology · 2026Review
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Authors and funding
15 authors.
Funding
Abstract
backgroundAseptic loosening and periprosthetic osteolysis driven by wear particles are major causes of total joint arthroplasty (TJA) failure. Investigating the upstream mechanisms of osteoblast ferroptosis in periprosthetic osteolysis is essential for developing therapeutic strategies to lengthen the lifespan of artificial joints.
methodTitanium nanoparticle (TN)-induced osteolysis models were established in vivo and in vitro. Bone parameters including bone mineral density, bone volume, bone volume to tissue volume ratio, and total porosity were measured by micro-CT in mice. Commercial kits were applied to test the levels of glutathione, malondialdehyde, and iron. BODIPY 581/591 C11 staining was used to detect lipid peroxidation. ChIP and dual-luciferase reporter assay were utilized to investigate the interaction among TCF4 protein and YTHDF1 promoter region. RIP was employed to detect the relationship between YTHDF1 and GPX4 or SLC7A11 mRNAs.
resultsOur findings revealed a marked enhancement of ferroptosis in clinical synovial tissues surrounding implants and TN-induced periprosthetic osteolysis models both in vitro and in vivo. Ferroptosis inhibitors significantly attenuated TN-induced osteolysis. TCF4 and YTHDF1 were both downregulated in TN-induced osteolysis, and overexpression of them improved bone microarchitecture and alleviated osteoblast ferroptosis. TCF4 bound to the promoter region of YTHDF1 to transcriptionally upregulate its expression, which subsequently promoted translation of GPX4 and SLC7A11 mRNAs. Finally, the activation of Wnt/β-catenin pathway boosted TCF4/YTHDF1 axis, and restrained osteoblast ferroptosis in osteolysis.
conclusionTCF4 targeted the promoter region of m6A reader YTHDF1 to promote its transcription, thereby reducing osteoblast ferroptosis in TN-induced periprosthetic osteolysis by promoting the translation of GPX4 and SLC7A11.
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