Evidence map›Paper›PMID 41430253›Full record

ArticleJournal of nanobiotechnology2025

Shape-fit 3D printed mineralized membrane for guided bone regeneration in long bone defects.

Wenbin Jiang, Yichen Zhan, Yuxuan Chen, Jiaming Sun, Qiuning Lin, Qiang He, Junpeng Ma, Bingkun Bao, Zhenxing Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenbin JiangDepartment of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yichen ZhanDepartment of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yuxuan ChenDepartment of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Jiaming SunDepartment of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Qiuning LinSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Qiang HeDepartment of Neurosurgery, West China Hospital, Sichuan University, Sichuan, Chengdu, 610041, China.
Junpeng MaDepartment of Neurosurgery, West China Hospital, Sichuan University, Sichuan, Chengdu, 610041, China. majunpenglj@163.com.
Bingkun BaoSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China. baobingkun@sjtu.edu.cn.
Zhenxing WangDepartment of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. benjamin.wzx@163.com.

Funding

Foundation of Wuhan WJ 2021Z008, 2023020201020502National Key Research and Development Program of China 2024YFC3407600National Key Research and Development Program of China No. 2024YFA1107600National Natural Science Foundation of China No. 82020108020National Natural Science Foundation of China No. 82322046Open Foundation of Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research 2024zsyx08, 2024KQHM02
6 · The paper itself

Abstract

Segmental large-sized long bone defects remain a significant challenge in clinical practice. The standard treatment, involving autologous or allogeneic graft implantation, is often insufficient due to the limited availability of donor bone. As an alternative therapy for long bone defects, guided bone regeneration (GBR) presents a promising approach, effectively enhancing bone augmentation by preventing bone defects from soft tissue infiltration and facilitating osteoblast migration. This technique employs a biomaterial membrane as a protective barrier on the bone surface, promoting osteogenesis. This study proposed a GBR membrane designed specifically for long bone defects for fabrication. A photocurable hydrogel and light-processing 3D printing, based on 3D-scanned long bone models, were utilized to achieve fabrication. A mineralization-inducing compound was also incorporated into the material to enhance cell adhesion and osteogenesis. The 3D-printed GBR membranes demonstrated precise attachment to the long bone surface, confirming successful fabrication. The efficacy of the 3D-printed GBR membranes was evaluated in rabbit radius bone defect models.

Indexed as

Bone RegenerationGuided Tissue RegenerationPrinting, Three-DimensionalAnimalsBiocompatible MaterialsCell AdhesionHydrogelsMembranes, ArtificialMiceOsteoblastsOsteogenesisRabbitsRadiusTissue ScaffoldsBiocompatible MaterialsHydrogelsMembranes, Artificial3D printingGuided bone regenerationHydrogelLong bone defectSurface mineralization

Identifiers

PMID41430253
PMCPMC12751345

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.