ArticleBiomedical engineering online2025
A comprehensive workflow for CCTA and OCT data fusion with 3D printing validation: advancing patient-specific testing environments for percutaneous coronary intervention devices.
Article in Biomedical engineering online, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo create high-resolution, patient-specific 3D coronary artery models aimed at developing digital models and functional phantoms for the testing of cardiac catheterization devices.
methodsUsing coronary computed tomography angiography (CCTA) and optical coherence tomography (OCT), coronary artery lesions were identified and quantified. Imaging data were fused using a custom-made workflow to create highly accurate digital 3D models. For validation of the workflow, coronary artery phantoms were fabricated using additive manufacturing. An OCT was then conducted on the 3D printed phantom, and the developed workflow was applied to generate a derivative model, which was subsequently compared to the original.
resultsCCTA and OCT datasets from 15 patients were successfully collected and used to develop patient-specific 3D coronary artery models, including detailed inner shells, calcifications, outer wall structures, and side branches. Of these, 13 out of 15 3D printed phantoms were successfully validated and compared to their corresponding original model. The median vertex deviation of the derivative model was 0.15 (0.14
conclusionWe present a novel workflow to produce high-resolution patient-specific phantoms of coronary arteries.
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