ArticleBMC endocrine disorders2025
Prevalence of dyslipidemia and associated factors among premenopausal and post-menopausal women: a community-based comparative cross-sectional study in Debre Markos city, Northwest, Ethiopia, 2024.
Article in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Exercise dose and triglyceride reduction in postmenopausal women: a systematic review and model-based network meta-analysis.Frontiers in physiology · 2026Review
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Abstract
backgroundHormonal changes, particularly in estrogen and follicle-stimulating hormone, during the menopausal transition affect lipid and glucose metabolism, thereby increasing the risk of dyslipidemia. Dyslipidemia is a well-recognized risk factor for cardiovascular disease, which remains the leading cause of death worldwide. Therefore, assessing dyslipidemia and its associated factors among women in the reproductive age group and those who have entered menopause may help reduce the risk of cardiovascular disease by promoting balanced lipid levels.
objectiveThe aim of this study was to determine and compare prevalence of dyslipidemia and associated factors among premenopausal and post-menopausal women: a community-based comparative cross-sectional study in Debre Markos city, Northwest, Ethiopia, 2024.
methodA community-based comparative cross-sectional study was conducted in Debre Markos city among 320 women. Participants were recruited using a multistage simple random sampling technique. Data were collected using a structured and pretested interviewer-administered questionnaire. Lipid profiles, estrogen, follicle-stimulating hormone, progesterone, luteinizing hormone, and glucose were measured using a Beckman Coulter analyzer. Data were analyzed using the Statistical Package for the Social Sciences (SPSS) version 27. Multivariable logistic regression was employed to identify predictors of dyslipidemia. In the multivariable logistic regression, a significant association was considered at p < 0.05 with odds ratios and 95% confidence intervals.
resultThe prevalence of dyslipidemia was 41.9% (95% CI: 34.2-49.6) among menopausal women and 22.5% (95% CI: 16.3-28.7) among premenopausal women. In menopausal women, physical inactivity (AOR = 3.04; 95% CI: 1.18-7.85), being obese (AOR = 3.08; 95% CI: 1.14-8.34), and low estrogen levels (≤ 30 pg/ml: AOR = 5.97; 95% CI: 1.88-18.93; 30.63-39.39 pg/ml: AOR = 3.73; 95% CI: 1.30-10.71) were significantly associated with dyslipidemia.
conclusionMenopausal women demonstrated a higher prevalence of dyslipidemia compared to their premenopausal counterparts. Independent of age, decreased estrogen levels, physical inactivity, and being obese were significant predictors of adverse lipid changes. These findings underscore the need for targeted preventive strategies during the menopausal transition to reduce the burden of dyslipidemia and improve women's long-term cardiovascular health and quality of life.
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