SynthesisBMC cancer2025
The impact of anxiety and depression on hematologic malignancy outcomes: a systematic review and meta-analysis.
Synthesis in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- MicroRNAs as potential prognostic biomarkers in acute lymphoblastic leukemia: a systematic review, meta-analysis, and bioinformatics study.Systematic reviews · 2026Pooled it
- Psychological distress as a putative host-state determinant of cancer immunotherapy response.Frontiers in immunology · 2026Review
- Correlation between mental health and pain-related impairment in patients with chronic cancer-related pain.Frontiers in psychology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundHematologic malignancies (HMs) are associated with high morbidity and mortality. Depression and anxiety, prevalent in patients with HM, may adversely impact survival, but their prognostic role remains unclear. MATERIALS AND
methodsThis systematic review and meta-analysis followed PRISMA guidelines and was registered in PROSPERO (CRD42024568789). We searched PubMed, SCOPUS, and Web of Science for studies examining the association between depression or anxiety and survival outcomes in patients with HMs. Data extraction and quality assessment (using the Newcastle-Ottawa Scale and RoB2) were conducted independently by multiple reviewers. Random-effects meta-analyses were performed, with subgroup, sensitivity, and publication bias analyses. Additionally, meta-regression analyses were used to explore the impact of study-level factors on the observed associations.
resultsTwenty-nine studies (31 cohorts) comprising 419,054 patients with various HMs were included. Depression was significantly associated with poorer OS (HR = 1.17, 95% CI: 1.09-1.27), while anxiety showed a non-significant association (HR = 1.20, 95% CI: 1.00-1.44). Depression was not significantly associated with EFS or CSS, however, anxiety was linked to poor EFS. Publication bias was detected, and adjustment attenuated the associations. Subgroup and sensitivity analyses confirmed the robustness of the main findings. Meta-regression indicated that heterogeneity in effect sizes was partially explained by sample size.
conclusionsDepression is associated with reduced overall survival in patients with HMs, underscoring the importance of psychological assessment and early intervention in this population. Further research is needed to clarify the impact of anxiety and to inform targeted supportive care strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.