Trial reportBMC anesthesiology2025
Remimazolam tosylate vs. propofol: effects on anesthetic efficacy and renal function in living donor kidney transplantation.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Abdominal Organ Transplantation: Noteworthy Literature in 2025.Seminars in cardiothoracic and vascular anesthesia · 2026Review
- Optimal Dosing Strategies for Remimazolam Across Diverse Patient Populations: A Clinical Narrative Review.Drug design, development and therapy · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundRemimazolam Tosylate (RT) is an ultrashort-acting benzodiazepine with organ-independent metabolism, suitable for patients with renal impairment. This study assessed the efficacy and safety of RT in living donor kidney transplantation.
methodsEighty-six patients with uremia who underwent living donor kidney transplantation from May 2024 to October 2024 were randomized into the RT group (group RT) or the propofol group (group P), with 43 patients per group. Induction in group RT was achieved with 0.2 mg/kg RT, followed by maintenance at a constant rate of 1 mg/kg/h. Induction in group P was achieved with 1.5 mg/kg propofol, followed by maintenance at a constant rate of 4-10 mg/kg/h. The primary outcomes were perioperative anesthetic efficacy and postoperative renal graft function. The secondary outcomes included perioperative electrolyte status, incidence of hypotension, and incidence of other adverse reactions.
resultsThe induction success rate was 100% in each group, and neither group required remedial sedative medication. However, the time to loss of consciousness in group RT was longer than that in group P (P < 0.05). Group RT had a longer time to eye opening and extubation compared with group P, but this difference was not significant (P > 0.05). Furthermore, the post-anesthesia care unit stay time for group RT was longer than that for group P (P < 0.05). No statistically significant difference was observed in postoperative renal function indicators or urine output between the two groups (P > 0.05). In addition, no delayed graft function (DGF) was observed in either group. The incidence of hypotension during the induction period in group RT was lower than that in group P (P < 0.05), and injection pain was also lower (P < 0.05).
conclusionsThe sedation effect in group RT was not worse than that in group P, with fewer hemodynamic fluctuations, lower injection pain, and without adverse effects on renal function. RT may thus represent a safer and organ-independent alternative for anesthesia in renal transplant recipients.
trial registrationThe study was registered in the Chinese Clinical Trial Registry at ChiCTR.org.cn (25/04/2024, ChiCTR2400083451).
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