Evidence map›Paper›PMID 41430073›Full record

ArticleScientific reports2025

Bridging pleiotropic mechanisms in leprosy type-1 reactions and neurodegenerative diseases.

Vinicius M Fava, Jônatas Perico, Marianna Orlova, Monica Dallmann-Sauer, Yong Zhong Xu, Nguyen Van Thuc, Vu Hong Thai, Andrea F Belone, Ana Carla P Latini, Erwin Schurr

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vinicius M FavaProgram in Infectious Diseases and Global Health, The Research Institute of the McGill University Health Centre, Montreal, Canada. vinicius.medeirosfava@mcgill.ca.
Jônatas PericoInstituto Lauro de Souza Lima, Bauru, São Paulo, Brazil.
Marianna OrlovaProgram in Infectious Diseases and Global Health, The Research Institute of the McGill University Health Centre, Montreal, Canada.
Monica Dallmann-SauerProgram in Infectious Diseases and Global Health, The Research Institute of the McGill University Health Centre, Montreal, Canada.
Yong Zhong XuProgram in Infectious Diseases and Global Health, The Research Institute of the McGill University Health Centre, Montreal, Canada.
Nguyen Van ThucHospital for Dermato-Venereology, Ho Chi Minh City, Vietnam.
Vu Hong ThaiHospital for Dermato-Venereology, Ho Chi Minh City, Vietnam.
Andrea F BeloneInstituto Lauro de Souza Lima, Bauru, São Paulo, Brazil.
Ana Carla P LatiniInstituto Lauro de Souza Lima, Bauru, São Paulo, Brazil.
Erwin SchurrProgram in Infectious Diseases and Global Health, The Research Institute of the McGill University Health Centre, Montreal, Canada.

Funding

Leprosy Research Initiative FP 22/9
6 · The paper itself

Abstract

Leprosy is an infectious disease of the skin and peripheral nervous system. Sudden episodes of hyperinflammation, known as Type 1 Reactions (T1R), are a main contributor to permanent nerve damage in leprosy. The genetic component associated with the neuro-inflammatory phenotype of T1R displays pleiotropic effects with Parkinson's disease (PD). In this study, we explored the genetic overlap between PD and T1R and expanded the evaluation of pleiotropic effects between T1R and other neurodegenerative disorders. We replicated the association of PD-linked rare variants in PRKN with T1R in Vietnamese leprosy patients. Analysis of 24 PD associated-genes revealed compound effects between rare protein-altering variants and T1R in the interacting genes PRKN/PINK1 (P = 2.7

Indexed as

Genetic PleiotropyLeprosyNeurodegenerative DiseasesParkinson DiseaseFemaleGenetic Predisposition to DiseaseHumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MaleMiddle AgedProtein KinasesPTEN-Induced Putative KinaseUbiquitin-Protein LigasesLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanparkin proteinProtein KinasesPTEN-Induced Putative KinaseUbiquitin-Protein Ligases

Identifiers

PMID41430073
PMCPMC12749272

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.