Evidence map›Paper›PMID 41430036›Full record

ArticleCell death & disease2025

Single-cell RNA sequencing identifies ZBP1-dependent mechanisms in OSCC progression.

Xuyang Lin, Chenlong Wang, Chaoyang Li, Jin Wu, Ping Zhang, Chengwan Zhang, Hao Chen, Fangyi Xu, Shuangyue Zhang, Chao Luo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xuyang Lin *Department of Oral Implantology, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.ORCID http://orcid.org/0009-0007-8885-1107
Chenlong Wang *Department of Central Laboratory, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Northern Jiangsu Institute of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Chaoyang Li *State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical University, Huai'an, Jiangsu Province, China.
Jin WuDepartment of Oral Implantology, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Ping ZhangState Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical University, Huai'an, Jiangsu Province, China.
Chengwan ZhangState Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical University, Huai'an, Jiangsu Province, China.
Hao ChenDepartment of Oral and Maxillofacial Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu Province, China.
Fangyi XuState Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical University, Huai'an, Jiangsu Province, China.
Shuangyue ZhangDepartment of Oral and Maxillofacial Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu Province, China. hayyzhshy@njmu.edu.cn.
Chao LuoDepartment of Central Laboratory, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Northern Jiangsu Institute of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China. hayylch@njmu.edu.cn.ORCID http://orcid.org/0000-0002-6233-3287
Chunbo TangDepartment of Oral Implantology, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China. cbtang@njmu.edu.cn.ORCID http://orcid.org/0000-0003-0286-004X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81972739
6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is a highly aggressive head and neck malignancy with a poor prognosis associated with its complex tumor microenvironment. Cancer-associated fibroblasts (CAFs) contribute to tumor progression by secreting various signaling molecules. This study investigates the molecular mechanism through which Z-DNA-binding protein 1 (ZBP1) promotes OSCC development through CAF regulation. To this end, orthotopic MOC1 transplantation and 4NQO-induced carcinogenesis OSCC models were established with Zbp1

Indexed as

DNA-Binding ProteinsMouth NeoplasmsRNA-Binding ProteinsSingle-Cell AnalysisSquamous Cell Carcinoma of Head and NeckAnimalsCancer-Associated FibroblastsCell Line, TumorCell ProliferationDisease ProgressionGene Expression Regulation, NeoplasticHumansMiceMice, KnockoutReceptors, CCR1Sequence Analysis, RNADNA-Binding ProteinsReceptors, CCR1RNA-Binding ProteinsZbp1 protein, mouse

Identifiers

PMID41430036
PMCPMC12749536

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.