Evidence map›Paper›PMID 41430001›Full record

ArticleAnalytical and bioanalytical chemistry2026

Untargeted metabolomics and lipidomics to study autophagy induction in mouse embryonic fibroblasts.

Rani Robeyns, Freke Mertens, Angela Sisto, Maria van de Lavoir, Maria Del Mar Delgado Povedano, Leen Jacobs, Wim Martinet, Adrian Covaci, Sigrid Stroobants, Vincent Timmerman and 1 more

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rani RobeynsToxicological Centre, University of Antwerp, 2610, Antwerp, Belgium. rani.robeyns@uantwerpen.be.ORCID http://orcid.org/0000-0002-3695-3490
Freke MertensPeripheral Neuropathy Research Group, University of Antwerp, 2610, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-6091-5291
Angela SistoPeripheral Neuropathy Research Group, University of Antwerp, 2610, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-7582-0623
Maria van de LavoirToxicological Centre, University of Antwerp, 2610, Antwerp, Belgium.ORCID http://orcid.org/0000-0001-7316-3319
Maria Del Mar Delgado PovedanoToxicological Centre, University of Antwerp, 2610, Antwerp, Belgium.ORCID http://orcid.org/0000-0001-8589-0812
Leen JacobsToxicological Centre, University of Antwerp, 2610, Antwerp, Belgium.ORCID http://orcid.org/0009-0001-6624-3799
Wim MartinetLaboratory of Physiopharmacology, University of Antwerp, 2610, Antwerp, Belgium.ORCID http://orcid.org/0000-0003-1967-9343
Adrian CovaciToxicological Centre, University of Antwerp, 2610, Antwerp, Belgium.ORCID http://orcid.org/0000-0003-0527-1136
Sigrid StroobantsDepartment of Nuclear Medicine, Antwerp University Hospital, 2630, Edegem, Belgium.ORCID http://orcid.org/0000-0002-6450-9944
Vincent TimmermanPeripheral Neuropathy Research Group, University of Antwerp, 2610, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-2162-0933
Alexander L N van NuijsToxicological Centre, University of Antwerp, 2610, Antwerp, Belgium. alexander.vannuijs@uantwerpen.be.ORCID http://orcid.org/0000-0002-9377-6160

Funding

Fonds Wetenschappelijk Onderzoek 1120623NFonds Wetenschappelijk Onderzoek 1S35920NFonds Wetenschappelijk Onderzoek 1SH1824NFonds Wetenschappelijk Onderzoek G014525NFonds Wetenschappelijk Onderzoek G040821NFonds Wetenschappelijk Onderzoek G0E5622NUniversiteit Antwerpen Antigoon database number 41222Universiteit Antwerpen BOF grantUniversiteit Antwerpen PS ID 513 41667
6 · The paper itself

Abstract

Autophagy is a complex self-degradative process that recycles cytoplasmic components through lysosomal degradation, enabling cells to maintain homeostasis during stress and nutrient deprivation. Despite major advances in understanding the basic mechanisms of autophagy, important gaps remain in translating them to human diseases. This study investigated the metabolic fingerprints and footprints of two mechanistically different autophagy inducers, Torin1 (mTOR-dependent) and Tat-Beclin1 (mTOR-independent), in mouse embryonic fibroblasts (MEF). Multi-platform untargeted metabolomics and lipidomics analyses were performed at 3 and 18 h exposure to elucidate both intracellular and extracellular metabolic changes using liquid chromatography-high-resolution mass spectrometry coupled to drift tube ion mobility, complemented by [

Indexed as

AutophagyFibroblastsLipidomicsMetabolomicsAnimalsChromatography, LiquidEmbryo, MammalianMass SpectrometryMiceMetabolic fingerprintingmTOR signalingStable-isotope tracingTat-Beclin1Torin1

Identifiers

PMID41430001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.