Evidence map›Paper›PMID 41429959›Full record

ArticleThe EMBO journal2026

Basonuclin-2 promotes fracture repair through NuRD-dependent chromatin remodeling in periosteal stem cells.

Zhong Zhang, Lingli Zhang, Bo Jiang, Shuqin Chen, Wenhui Xing, Peilong Wang, Lixiang Lou, Chunxiao Tang, Xuye Hu, Jinlong Suo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhong Zhang *Hainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China.ORCID http://orcid.org/0000-0002-2636-3921
Lingli Zhang *School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China.
Bo Jiang *Hainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China.
Shuqin ChenHainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China.
Wenhui XingHainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China.
Peilong WangKey Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Lixiang LouKey Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Chunxiao TangHainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China.
Xuye HuKey Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Jinlong SuoKey Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.ORCID http://orcid.org/0000-0003-3389-3776
Bo O ZhouKey Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.ORCID http://orcid.org/0000-0001-8950-8799
Weiguo ZouHainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China. zouwg94@sibcb.ac.cn.ORCID http://orcid.org/0000-0003-2516-0302
Lijun WangHainan Institute of Regenerative Orthopedics and Sports Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Hainan, 571199, China. wanglijun2014@sibcb.ac.cn.ORCID http://orcid.org/0000-0002-3686-6098

Funding

MOST | National Natural Science Foundation of China (NSFC) 82102554MOST | National Natural Science Foundation of China (NSFC) 82230082MOST | National Natural Science Foundation of China (NSFC) 82272608MOST | National Natural Science Foundation of China (NSFC) 82502903MOST | National Natural Science Foundation of China (NSFC) 82530082Space Medical Experiment Project of China Manned Space Program HYZHXM01025The Strategic Priority Research Program of the Chinese Academy of Science XDB0570000
6 · The paper itself

Abstract

Bone fracture healing remains a significant challenge in orthopedics, as injury-responsive skeletal stem cell (SSC) populations and the regulatory mechanisms governing SSC activation during nonunion fracture repair remain poorly delineated. This study identifies zinc finger transcription factor basonuclin-2 (BNC2) as a skeletal fracture repair control factor in periosteal stem cells. BNC2 marks quiescent periosteal cells during homeostasis and is significantly upregulated upon injury in mice, driving endochondral ossification post-fracture via clonal expansion. Moreover, knockout of Bnc2 in Prx1-cre

Indexed as

Chromatin Assembly and DisassemblyDNA-Binding ProteinsFracture HealingPeriosteumStem CellsTranscription FactorsAnimalsCell ProliferationHistone Deacetylase 1Histone Deacetylase 2MiceMice, KnockoutOsteogenesisDNA-Binding ProteinsHdac2 protein, mouseHistone Deacetylase 1Histone Deacetylase 2Transcription FactorsBnc2Fracture HealingNuRD ComplexPeriosteal Skeletal Stem Cells

Identifiers

PMID41429959
PMCPMC12910080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.