Evidence map›Paper›PMID 41429954›Full record

Observational studyPediatric research2026

Pain Assessment During Less Invasive Surfactant Administration Using Skin Conductance: A Prospective Cohort Study.

Coralie Dirler, Vinzenz Boos, Dirk Bassler, Stephan Benke-Bruderer, Ulrike Held, Christoph M Rüegger, Tobias Muehlbacher

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06150586 (The PALISA Study - Pain Assessment During Less-Invasive-Surfactant-Administration), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06150586 completednot on this map

The PALISA Study - Pain Assessment During Less-Invasive-Surfactant-Administration

TypeobservationalSponsorUniversity of ZurichRan2023 to 2024Enrolled21ConditionsInfant, Premature, Diseases, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal, PainArmsSkin Conductance (SC) Measurement, Video Recording
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Coralie DirlerNewborn Research, Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Vinzenz BoosNewborn Research, Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-6895-4861
Dirk BasslerNewborn Research, Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Stephan Benke-BrudererClinical Trials Center, University Hospital Zurich, Zurich, Switzerland.
Ulrike HeldEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Christoph M RüeggerNewborn Research, Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Tobias MuehlbacherNewborn Research, Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. tobias.muehlbacher@usz.ch.ORCID http://orcid.org/0000-0001-8661-9645

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLess Invasive Surfactant Administration (LISA) is an established treatment for surfactant deficiency. However, analgosedation for LISA remains controversial. The aim of this study was to assess pain using skin conductance (SC) measurements during LISA.

methodsThis prospective cohort study included preterm infants born at ≥27 weeks. Pain was assessed using SC and blinded Neonatal Pain, Agitation and Sedation Scale (N-PASS) scoring. Primary outcome was change to baseline in SC peaks per second (PPS) at pre-specified events. Secondary outcomes included N-PASS scores and changes in cardiorespiratory parameters.

resultsTwenty infants were included in the analysis. SC-PPS were increased during nasopharyngeal tube (NPT) insertion, but no more significant after adjusting for chronological age. SC-PPS were not increased at any other pre-specified event during LISA. N-PASS scores indicated elevated pain levels during NPT insertion (Δ

conclusionLISA was not associated with elevated SC-PPS, despite increased N-PASS scores during specific procedural steps. This may reflect technical limitations of SC monitoring immediately after birth in preterm infants. CLINICAL

trial registrationClinicalTrials.gov (NCT06150586) IMPACT: Skin conductance (SC) measurement has been proposed as an objective method for pain assessment in preterm infants. In our study, SC did not indicate a pain response in infants undergoing Less Invasive Surfactant Administration (LISA). Our findings suggest that SC alone may not be a reliable indicator of procedural pain in preterm infants shortly after birth. There remains a critical need for objective methods to assess pain in preterm infants. Further research is required to validate SC for neonatal pain assessment.

Indexed as

Galvanic Skin ResponsePainPain MeasurementPulmonary SurfactantsFemaleHumansInfant, NewbornInfant, PrematureLaryngoscopyMaleProspective StudiesPulmonary Surfactants

Identifiers

PMID41429954
PMCPMC13638450

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Registered trials

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