ArticleJournal of exposure science & environmental epidemiology2026
A comparative study of urinary mycotoxin biomarkers co-occurrence patterns and cumulative risk assessment in population from three typical areas in China.
Article in Journal of exposure science & environmental epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis biomonitoring study investigated levels of multi-mycotoxin biomarkers in the urine of subjects living in three different geographic locations and dietary patterns in China.
objectiveThis study provides a comprehensive understanding of the inner-exposure characteristics to multiple mycotoxins within the Chinese population.
methodsThe study involved a total of 311 healthy volunteers, with 103 from Anhui Province, 102 from Henan Province, and 106 from Sichuan Province. UHPLC-MS/MS was employed to analyze seven mycotoxin biomarkers [total deoxynivalenol (DONt), β-zearalenol (β-ZEL), nivalenol (NIV), α-zearalenol (α-ZEL), diacetoxycyclohexenol (DAS), zearalenone (ZEN), aflatoxin M
resultsIn the study population, DON was the most prevalent (100%) with a mean concentration of 90.77 ng/ml, followed by β-ZEL (27.97%), NIV (24.76%), α-ZEL (24.12%), DAS (12.86%), ZEN (6.11%) and AFM IMPACT: In the present study, the co-occurrence pattern and cumulative risk of the metabolite biomarkers of multi-mycotoxins were firstly revealed in three typical areas with different climate types and dietary patterns. This study helps assess the health risks of mycotoxin exposure under different environmental and dietary conditions, reveals the relationship between diet and mycotoxin exposure, and provides scientific support for mitigating the harmful effects of mycotoxins on human health.
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