Evidence map›Paper›PMID 41429925›Full record

ArticleCommunications biology2025

Mitochondrial proteostasis regulated by CRL5

Yvan Campos, Gustavo Palacios, Elida Gomero, Diantha van de Vlekkert, Krishnan Venkataraman, Jaison John, Jason Andrew Weesner, Randall Wakefield, Xiaohui Qiu, Ricardo Rodriguez-Enriquez and 8 more

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Relaxin-2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yvan CamposDepartment of Genetics, St. Jude Children's Research Hospital, Memphis, TN, USA. yvan.campos@stjude.org.ORCID http://orcid.org/0000-0002-9820-0339
Gustavo PalaciosDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0009-0001-2483-3774
Elida GomeroDepartment of Genetics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Diantha van de VlekkertDepartment of Genetics, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-7498-1292
Krishnan VenkataramanCenter for Bioimage Informatics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jaison JohnCenter for Bioimage Informatics, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0009-0000-2825-0675
Jason Andrew WeesnerDepartment of Genetics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Randall WakefieldCell and Tissue Imaging Center, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-6233-8109
Xiaohui QiuDepartment of Genetics, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-5767-0422
Ricardo Rodriguez-EnriquezDepartment of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-1997-0608
Stephanie RockfieldDepartment of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jeroen DemmersProteomics Center, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-8757-9611
Joseph T OpfermanDepartment of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-1147-5621
Cam RobinsonCell and Tissue Imaging Center, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-7277-692X
Khaled KhairyCenter for Bioimage Informatics, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-9274-5928
Tulio BertoriniDepartment of Neurology, University of Tennessee Heath Science Center, Memphis, TN, USA.
Gerard C GrosveldDepartment of Genetics, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-6583-1265
Alessandra d'AzzoDepartment of Genetics, St. Jude Children's Research Hospital, Memphis, TN, USA. sandra.dazzo@stjude.org.ORCID http://orcid.org/0000-0003-1747-7502

Funding

U.S. Department of Health & Human Services | NIH | Center for Information Technology (Center for Information Technology, National Institutes of Health) AR049867U.S. Department of Health & Human Services | NIH | Center for Information Technology (Center for Information Technology, National Institutes of Health) CA021764U.S. Department of Health & Human Services | NIH | Center for Information Technology (Center for Information Technology, National Institutes of Health) GM104981
6 · The paper itself

Abstract

High-energy-demanding tissues, such as skeletal muscle, rely on mitochondrial proteostasis for proper function. Two key quality-control mechanisms -the ubiquitin proteasome system (UPS) and the release of mitochondria-derived vesicles- help maintain mitochondrial proteostasis, but whether these processes interact remains unclear. Here, we show that CRL5

Indexed as

MitochondriaMitochondrial ProteinsMitochondria, MuscleMuscle Fibers, SkeletalMuscle, SkeletalProteostasisAnimalsHumansMaleMiceMice, Inbred C57BLMice, KnockoutMitochondrial Proteins

Identifiers

PMID41429925
PMCPMC12953697

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.