Evidence map›Paper›PMID 41429887›Full record

ArticleCommunications biology2025

Propofol addiction drives neuronal senescence and cognitive decline via autophagy-mediated ADAR1/SIRT1 disruption.

Xidi Wang, Shounuo Lin, Zhiting Zou, Dan Zhu, Jiahui Zhou, Xiaoyu Zhang, Jianan Lv, Wenhua Zhou, Yu Liu, Zizhen Si

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xidi WangMedical Research Center, The First Affiliated Hospital of Ningbo University, Ningbo, PR China.ORCID http://orcid.org/0000-0001-7924-5120
Shounuo LinAddiction treatment laboratory of Zhejiang, Hangzhou, China.
Zhiting ZouDepartment of Psychology, Collage of Teacher Education, Ningbo University, Ningbo, China.
Dan ZhuSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, China.
Jiahui ZhouSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, China.
Xiaoyu ZhangDepartment of Psychology, Collage of Teacher Education, Ningbo University, Ningbo, China.
Jianan LvSchool of Pharmacy, Health Science Center, Ningbo University, Ningbo, China.
Wenhua ZhouDepartment of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo, China.
Yu LiuSchool of Pharmacy, Health Science Center, Ningbo University, Ningbo, China. liuyu@nbu.edu.cn.
Zizhen SiSchool of Pharmacy, Health Science Center, Ningbo University, Ningbo, China. sizizhen@nbu.edu.cn.ORCID http://orcid.org/0000-0001-8106-9816

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Propofol addiction represents a significant clinical challenge with no approved pharmacotherapy. While cognitive decline is a hallmark of substance use disorders, its underlying mechanisms in propofol addiction remain unclear. This study investigates whether propofol abuse induces neuronal senescence and cognitive impairment and explores the involved molecular pathways. We found that propofol administration in mice led to significant learning and memory deficits, which were associated with p16

Indexed as

Adenosine DeaminaseAutophagyCellular SenescenceCognitive DysfunctionNeuronsPropofolRNA-Binding ProteinsSirtuin 1Substance-Related DisordersAnimalsCyclin-Dependent Kinase Inhibitor p16MaleMiceMice, Inbred C57BLAdenosine DeaminaseCyclin-Dependent Kinase Inhibitor p16PropofolRNA-Binding ProteinsSirt1 protein, mouseSirtuin 1

Identifiers

PMID41429887
PMCPMC12749188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.