ArticleScientific reports2025
HPV16-miR-H1 promotes proliferation, migration, and glycolysis in head and neck squamous cell carcinoma cells via the PTEN/AKT pathway.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Human papillomavirus-encoded microRNAs: key regulators in cervical cancer development.RNA biology · 2026Review
- Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human papillomavirus type 16 (HPV16) is the most common type of infection in head and neck squamous cell carcinoma (HNSCC).The HPV16-encoded miRNA, HPV16-miR-H1, has been validated in cervical cancer tissues and cells, but its role in the pathogenesis of HNSCC remains unclear. The expression level of HPV16-miR-H1 in HNSCC cells was detected, and its mechanism of action was analyzed using bioinformatics tools and RNA sequencing. Overexpression and knockdown of HPV16-miR-H1 were performed to validate its regulatory effects on the PTEN/AKT axis and its impact on cell proliferation, migration, the cell cycle, and glycolysis. HPV16-miR-H1 was highly expressed in HPV16-positive HNSCC cells. Bioinformatics prediction and gene enrichment analysis indicated that HPV16-miR-H1 regulates PTEN transcription and the glycolysis process. Dual-luciferase reporter assays further confirmed that HPV16-miR-H1 targets the 3’-UTR region of PTEN. Functional experiments demonstrated that HPV16-miR-H1 affects HNSCC cell proliferation, migration, the cell cycle, and glycolysis. The expression of HPV16-miR-H1 in HNSCC cells was validated for the first time. Further studies revealed that it regulates the PTEN/AKT axis by targeting the 3’UTR region of PTEN, thereby enhancing the proliferation, migration, and glycolytic processes in HNSCC cells.
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