Evidence map›Paper›PMID 41429774›Full record

ArticleNature communications2025

Structural insights into AQP3 channel closure upon pH and redox changes reveal an autoregulatory molecular mechanism.

Peng Huang, Raminta Venskutonytė, Carter J Wilson, Sara Bsharat, Rashmi B Prasad, Pontus Gourdon, Isabella Artner, Bert L de Groot, Karin Lindkvist-Petersson

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peng Huang *Department of Experimental Medical Science, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0001-8556-5606
Raminta Venskutonytė *Department of Experimental Medical Science, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0003-0650-0180
Carter J Wilson *Computational Biomolecular Dynamics Group, Max Planck Institute for Multidisciplinary Sciences, Gottingen, Germany.ORCID http://orcid.org/0000-0002-8992-6269
Sara BsharatLund University Diabetes Centre, Clinical Research Center, Malmo, Sweden.
Rashmi B PrasadLund University Diabetes Centre, Clinical Research Center, Malmo, Sweden.ORCID http://orcid.org/0000-0002-4400-6741
Pontus GourdonDepartment of Experimental Medical Science, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0002-8631-3539
Isabella ArtnerLund University Diabetes Centre, Clinical Research Center, Malmo, Sweden.ORCID http://orcid.org/0000-0002-2895-5664
Bert L de GrootComputational Biomolecular Dynamics Group, Max Planck Institute for Multidisciplinary Sciences, Gottingen, Germany.ORCID http://orcid.org/0000-0003-3570-3534
Karin Lindkvist-PeterssonDepartment of Experimental Medical Science, Lund University, Lund, Sweden. karin.lindkvist@med.lu.se.ORCID http://orcid.org/0000-0002-5209-3160

Funding

Cancerfonden (Swedish Cancer Society) 20 0747 PjFCancerfonden (Swedish Cancer Society) 23 2746 PjDiabetesfonden (Stiftelsen Svenska Diabetesförbundets Forskningsfond) DIA2020-500Vetenskapsrådet (Swedish Research Council) 2024-02673
6 · The paper itself

Abstract

Regulation of intracellular levels of reactive oxygen species (ROS) remains poorly understood. Aquaporin 3 (AQP3) facilitates the membrane transport of hydrogen peroxide (H

Indexed as

Aquaporin 3Cryoelectron MicroscopyHomeostasisHumansHydrogen-Ion ConcentrationHydrogen PeroxideInsulin-Secreting CellsOxidation-ReductionProtein ConformationReactive Oxygen SpeciesAQP3 protein, humanAquaporin 3Hydrogen PeroxideReactive Oxygen Species

Identifiers

PMID41429774
PMCPMC12722722

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.