Evidence map›Paper›PMID 41429681›Full record

Trial reportThe journal of pain2026

Long-lasting effect of penetrating acupuncture among responders: Double-blind RCT of acupuncture for vulvodynia.

Judith M Schlaeger, Alana D Steffen, Nobuari Takakura, William H Kobak, Miho Takayama, Hiroyoshi Yajima, Marie L Suarez, Monya Meinel, Larisa A Burke, Heather A Pauls and 6 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in The journal of pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Judith M SchlaegerUniversity of Illinois Chicago, College of Nursing, Department of Human Development Nursing Science, United States. Electronic address: jschlaeg@uic.edu.
Alana D SteffenUniversity of Illinois Chicago, College of Nursing, Department of Population Health Nursing Science, United States.
Nobuari TakakuraTokyo Ariake University of Medical and Health Sciences, Faculty of Health Sciences, Department of Acupuncture and Moxibustion, Japan.
William H KobakUniversity of Illinois Chicago, College of Medicine, Department of Obstetrics and Gynecology, United States.
Miho TakayamaTokyo Ariake University of Medical and Health Sciences, Faculty of Health Sciences, Department of Acupuncture and Moxibustion, Japan.
Hiroyoshi YajimaTokyo Ariake University of Medical and Health Sciences, Faculty of Health Sciences, Department of Acupuncture and Moxibustion, Japan.
Marie L SuarezUniversity of Illinois Chicago, College of Nursing, Department of Human Development Nursing Science, United States.
Monya MeinelUniversity of Illinois Chicago, College of Nursing, Department of Human Development Nursing Science, United States.
Larisa A BurkeUniversity of Illinois Chicago, College of Nursing, Office of Research Facilitation, United States.
Heather A PaulsUniversity of Illinois Chicago, College of Nursing, Office of Research Facilitation, United States.
Yingwei YaoUniversity of Florida College of Nursing, Department of Biobehavioral Nursing Science, United States.
Katelyn M SullivanUniversity of Illinois Chicago, College of Nursing, Department of Human Development Nursing Science, United States.
Jennifer E GlayzerUniversity of Illinois Chicago, College of Nursing, Department of Human Development Nursing Science, United States.
David C FosterUniversity of Rochester School of Medicine and Dentistry, United States.
Ted J KaptchukBeth Israel Deaconess Medical Center/Harvard Medical School, Program in Placebo Studies, United States.
Diana J WilkieUniversity of Florida College of Nursing, Department of Biobehavioral Nursing Science, United States.

Funding

Double-blind Phase 2 RCT: Effect of Acupuncture on Patient Vulvodynia OutcomesR01HD091210 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SCHLAEGER, JUDITH MICHELLE · 2017 to 2021
$2.0M
NICHD NIH HHS R01 HD091210
6 · The paper itself

Abstract

Vulvodynia, vulvar pain of unknown etiology, lasting 3 months or longer, affects 7% of American women, and has no consistently effective treatment. We aimed to test the efficacy of acupuncture on vulvar pain and dyspareunia and explore the duration of the effect in a double-blind randomized controlled trial of acupuncture for vulvodynia. 89 women, 19-62 years old (mean 30.2 ± 8.3), 70% White, 20% Hispanic; 91% completed a 13-needle, 10-session standardized acupuncture protocol using double-blind acupuncture needles. Average Pain Intensity of vulvar pain (API, 0-10 scale) and dyspareunia (Female Sexual Function Index) were measured at baseline and after the 10th treatment. Participants with a clinically important post-treatment improvement reported weekly Tampon Test scores (0-10), a measure of provoked vulvar pain, until they returned to baseline. Percentage of responders was similar: acupuncture 58%, placebo 57%; no significant differences were found between acupuncture and placebo groups on API or dyspareunia upon completion of treatments. Responders showed a consistently higher rate of return to baseline pain during the 12-week post-treatment follow-up in the placebo group compared to the acupuncture group (hazard ratio: 2.72, 95% CI: 1.13-6.54). Effects of acupuncture on vulvodynia may have been underestimated because of the strong placebo response from the skin-touch placebo needles. Among responders, the relatively large placebo effect did not persist for as many participants as the therapeutic effect of penetrating acupuncture during the 12-week follow up. Findings indicate investigations into the effects among acupuncture responders and non-responders are warranted. Findings also merit larger, pragmatic trials. PERSPECTIVE: Double-blind RCT of acupuncture for vulvodynia tested vulvar pain and dyspareunia and explored the duration of effect. Penetrating acupuncture and skin-touch placebo needle groups had pain reduction, not significantly different between groups. Pain reduction lasted longer for significantly more responders in the penetrating acupuncture vs. skin-touch placebo groups.

Indexed as

Acupuncture TherapyVulvodyniaAdultDouble-Blind MethodDyspareuniaFemaleHumansMiddle AgedPain MeasurementTime FactorsTreatment OutcomeYoung AdultAcupunctureChronic painDouble-blind acupuncture needlesPlaceboPlacebo acupunctureSham acupunctureVulvodynia

Identifiers

PMID41429681
PMCPMC12723140

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.