Evidence map›Paper›PMID 41429665›Full record

ArticleNeuropsychopharmacology reports2026

Evaluation of GABAergic and Glutamatergic Levels in the Dorsal Anterior Cingulate Cortex of Patients With Bipolar Disorder: A Cross-Sectional

Sotaro Moriyama, Yoshihiro Noda, Shiori Honda, Richard A E Edden, Koki Takahashi, Keisuke Saito, Keita Taniguchi, Masataka Wada, Sakiko Tsugawa, Yui Tobari and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sotaro MoriyamaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0001-8142-5665
Yoshihiro NodaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Shiori HondaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Richard A E EddenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Koki TakahashiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Keisuke SaitoDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Keita TaniguchiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0009-0002-0643-8452
Masataka WadaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Sakiko TsugawaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Yui TobariDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Sunjun HuhDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Yumina NakaneDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Saki HommaGraduate School of Media and Governance, Keio University, Kanagawa, Japan.ORCID https://orcid.org/0009-0001-0699-0557
Mie MatsuiDepartment of Clinical Cognitive Neuroscience, Institute of Liberal Arts and Science, Kanazawa University, Kanazawa, Japan.
Shinsuke KoikeCenter for Evolutionary Cognitive Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.
Masaru MimuraDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Hiroyuki UchidaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0002-0628-7036
Shinichiro NakajimaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0003-4229-1910

Funding

Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Stewart H Mostofsky · 2020 to 2026
$9.9M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Universal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4M
Simultaneous Hadamard Editing of GABA and GlutathioneR01EB023963 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2017 to 2024
$3.8M
Daiichi Sankyo, Eisai, Mochida, Otsuka, and Sumitomo PharmaJapan Agency for Medical Research and Development JP18dm0307004Japan Agency for Medical Research and Development JP19dm0207069Japan Agency for Medical Research and Development JP23tm0524002Japan Agency for Medical Research and Development JP24wm0625302Japan Agency for Medical Research and Development JP24wm0625307Japan Science and Technology Agency JPMJFR231QJapan Society for the Promotion of Science 18H02755Japan Society for the Promotion of Science 21H02813Japan Society for the Promotion of Science 22H03002Japan Society for the Promotion of Science JP20KK0193Japan Society for the Promotion of Science JP21H02851Japan Society for the Promotion of Science JP21H05324Japan Society for the Promotion of Science JP22H05212Japan Society for the Promotion of Science JP23H02865Japan Society for the Promotion of Science JP23H03877Japan Society for the Promotion of Science JP24H00899Japan Society for the Promotion of Science JP24K02378NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963NICHD NIH HHS P50 HD103538SENSHIN Medical Research FoundationTakeda Science FoundationTeijin Pharma Ltd. and Inter-Reha Co. LtdWatanabe Foundation and the Daiichi Sankyo Scholarship Donation Program
6 · The paper itself

Abstract

backgroundImbalances between excitatory and inhibitory (E/I) neurotransmitters in the brain may contribute to the pathophysiology of bipolar disorder (BD). Proton magnetic resonance spectroscopy (

methodsWe conducted a cross-sectional study using

resultsNo significant differences in dACC GABA levels, Glx levels, or Glx/GABA ratio were observed between the BD and HC groups. There were no significant differences within the BD group based on BD subtype (I or II) or clinical phase (depression or euthymic). Patients with lithium treatment had higher GABA levels compared to those without. DISCUSSION: Our results suggest that GABAergic function in the dACC may not play a pivotal role in the pathophysiology of BD. Given possible GABAergic dysregulation in BD, further research using alternative methodologies is warranted to elucidate the pathological basis.

Indexed as

Bipolar Disordergamma-Aminobutyric AcidGlutamic AcidGlutamineGyrus CinguliAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedProton Magnetic Resonance Spectroscopygamma-Aminobutyric AcidGlutamic AcidGlutaminebipolar disorderdorsal anterior cingulate cortexglutamate/glutamineproton magnetic resonance spectroscopyγ‐aminobutyric acid

Identifiers

PMID41429665
PMCPMC12722104

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.