ArticleOrganic letters2026
Rh-Catalyzed Cycloaddition Cascade of Allenynes and Maleimides: A Powerful Strategy for Constructing Complex Pentacyclic Structures with a Bicyclo[2.2.2]octene Core.
Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Triphenylmethyl Group as a Highly DiastereoselectiveMolecules (Basel, Switzerland) · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein, we report that 1,5- and 1,6-allenynes react with two equivalents of maleimide to afford pentacyclic frameworks featuring a bicyclo[2.2.2]octene core in a fully diastereoselective fashion. DFT calculations and deuterium-labeling studies reveal an unconventional mechanism initiated by a noncanonical [2 + 2 + 2] cycloaddition that, through intramolecular hydrogen shifts, diverges from the classical pathway to generate a conjugated diene. A subsequent thermal Diels-Alder reaction with a second maleimide completes the cascade, unveiling a distinct reactivity mode.
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Registered trials
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