Bicyclo[1.1.1]pentane Ketones via Friedel-Crafts Acylation.

Karolina Urbańska, Freya Ritterling, Brendan Twamley, Oliver Cseh, Vitalina Levchenko, Vasyl Ripenko, Pavel K Mykhailiuk, Mathias O Senge

Abstract read

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In one paragraph

Article in The Journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karolina UrbańskaSchool of Chemistry, Trinity Biomedical Sciences Institute, Trinity College Dublin, The University of Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland.

Freya RitterlingSchool of Chemistry, Trinity Biomedical Sciences Institute, Trinity College Dublin, The University of Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland.

Brendan TwamleySchool of Chemistry, Trinity College Dublin, The University of Dublin, Dublin 2 D02 CX56, Ireland.

Oliver CsehSchool of Chemistry, Trinity Biomedical Sciences Institute, Trinity College Dublin, The University of Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland.

Vitalina LevchenkoEnamine Ltd, Winston Churchill Str. 78, Kyiv 02094, Ukraine.

Vasyl RipenkoEnamine Ltd, Winston Churchill Str. 78, Kyiv 02094, Ukraine.

Pavel K MykhailiukEnamine Ltd, Winston Churchill Str. 78, Kyiv 02094, Ukraine.ORCID 0000-0003-1821-9011

Mathias O SengeInstitute for Advanced Study (TUM-IAS), Technical University of Munich, Lichtenbergstr. 2a, Garching 85748, Germany.ORCID 0000-0002-7467-1654

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bicyclo[1.1.1]pentane (BCP) is a rigid aliphatic hydrocarbon with a three-dimensional (3D), propeller-like shape and a molecular size that makes it a targeted bioisosteric replacement for phenylene and acetylene groups in medicinal chemistry. For the pharmaceutical application of BCP, simple, efficient, and cost-effective synthetic tools are required to enable the exploration of BCP's potential as a bioisostere across a broad chemical space. With numerous sophisticated protocols for C(sp

Identifiers

PMID41428950

DOI10.1021/acs.joc.5c01754

PMCPMC12797227

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.