Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
20 authors.
Samuel B SniderDivision of Neurocritical Care, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115.ORCID 0000-0002-6965-7890
Hui ShiDivision of Neurocritical Care, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115.ORCID 0009-0006-1096-5836
Yelena G BodienDepartment Surgery, Vanderbilt University Medical Center, Nashville, TN 37212.
Calvin HowardCenter for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry and Radiology, Brigham and Women's Hospital, Boston, MA 02115.
Xiaoying SunBiostatistics Research Center, Herbert Wertheim School of Public Health, University of California San Diego, San Diego, CA 92122.
Alexandra J GolbyHarvard Medical School, Boston, MA 02115.
Karl A ZimmermanUnited Kingdom Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London NW1 3BT, United Kingdom.ORCID 0000-0003-1239-3414
Guido BertoliniDepartment of Medical Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo 24126, Italy.ORCID 0000-0002-3101-4259
Sandra MagnoniAnesthesiology and Pain Medicine Service, Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari 07100, Italy.ORCID 0000-0002-1723-0844
Vincent DunetRadiology Department, Lausanne University Hospital (CHUV), Lausanne 1011, Switzerland.ORCID 0000-0002-9897-4561
Mauro OddoClinical Research Center and Directorate of Innovation and Clinical Research, Lausanne University Hospital (CHUV), Faculty of Biology and Medicine, University of Lausanne, Lausanne 1011, Switzerland.ORCID 0000-0002-6155-2525
Neil S N GrahamUnited Kingdom Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London NW1 3BT, United Kingdom.
Emma-Jane MallasUnited Kingdom Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London NW1 3BT, United Kingdom.
Federico MoroDepartment of Acute Brain and Cardiovascular Injury, Istituto di Ricerche Farmacologiche Mario Negri Istituto di Ricovero e Cura a Carattere Scientifico, Milan 20156, Italy.ORCID 0000-0002-2682-5583
Pratik MukherjeeDepartment of Radiology, University of California San Francisco, San Francisco, CA 94143.ORCID 0000-0001-7473-7409
Nancy R TemkinDepartment of Neurological Surgery, University of Washington, Seattle, WA 98195.ORCID 0000-0002-6392-5292
Sonia JainBiostatistics Research Center, Herbert Wertheim School of Public Health, University of California San Diego, San Diego, CA 92122.ORCID 0000-0001-8408-1247
David J SharpUnited Kingdom Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London NW1 3BT, United Kingdom.
Michael D Fox *Harvard Medical School, Boston, MA 02115.
Funding
BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)UM1NS132358 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Suzanne N Haber, Elizabeth M. C. Hillman · 2023 to 2026
$17.5M
Using human brain connectivity to identify the causal neuroanatomical substrate of depression symptomsR01MH113929 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2017 to 2026
$6.9M
Clinical & biological signatures of post-traumatic neurodegeneration: Leveraging the TBI Model Systems of Care to accelerate in vivo diagnosis of the late effects of TBI (LETBI)RF1NS128961 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAMS-O'CONNOR, KRISTEN · 2022 to 2022
$5.0M
Toward Connectomic Deep Brain Stimulation in Obsessive Compulsive DisorderR01MH130666 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.9M
Using Brain Lesions and Deep Brain Stimulation to Identify an Epilepsy CircuitR01NS127892 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.4M
Clinical & biological signatures of post-traumatic neurodegeneration: Leveraging the TBI Model Systems of Care to accelerate in vivo diagnosis of the late effects of TBI (LETBI)R01NS128961 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Kristen Dams-O'Connor · 2025 to 2026
$3.3M
SNSPD-DCS at 1064 nm for non-invasive monitoring of cerebral perfusion and intracranial pressure in the ICUU01EB034228 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Maria Angela Franceschini · 2023 to 2026
$2.9M
A Connectome-Based Clinical Trial Platform to Promote Early Recovery of Consciousness after Traumatic ComaDP2HD101400 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI EDLOW, BRIAN L. · 2019 to 2019
$2.5M
A molecular dissection of BK channelopathy in neurological disordersR01NS138258 · NINDS · WASHINGTON UNIVERSITY · PI Jianmin Cui, Huanghe Yang · 2025 to 2026
$1.3M
Predicting Dependency after Traumatic Brain InjuryK23NS136767 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI Samuel Snider · 2024 to 2026
$685k
Identifying neuromodulation targets for pain in the human brainR21NS123813 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI FOX, MICHAEL D · 2022 to 2023
$492k
Targeted modulation of symptom-specific brain circuits with transcranial magnetic stimulationR21MH126271 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI FOX, MICHAEL D · 2021 to 2022
$492k
American Heart Association (AHA) CDAHHS | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) U01EB034228HHS | NIH | National Institute of Mental Health (NIMH) R01MH113929HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 1K23NS136767HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS128961HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS138258NIBIB NIH HHS U01 EB034228NICHD NIH HHS DP2 HD101400NIMH NIH HHS R01 MH113929NIMH NIH HHS R01 MH130666NIMH NIH HHS R21 MH126271NINDS NIH HHS K23 NS136767NINDS NIH HHS R01 NS127892NINDS NIH HHS R01 NS128961NINDS NIH HHS R01 NS138258NINDS NIH HHS R21 NS123813NINDS NIH HHS RF1 NS128961NINDS NIH HHS UM1 NS132358
6 · The paper itself
Abstract
Some patients with moderate to severe traumatic brain injury (TBI) make a full recovery, while others remain severely disabled. Accurate prognostication is important, because withdrawal of life-sustaining therapy based on perceived poor prognosis is the leading cause of death after TBI. Synchronized activity between brain regions, measurable with resting-state functional MRI (rs-fMRI), may underlie neurological recovery. However, which functional connections are critical for recovery, and whether functional connectivity measured shortly after brain injury predicts long-term recovery, is unknown. Here, we analyzed data from three prospective cohorts of patients with moderate or severe TBI (N = 116 patients; 134 controls) who underwent rs-fMRI shortly after injury. The strongest predictor of 6-mo functional outcomes in the Training Cohort (mean cross validation AUC 0.94) and independent Testing Cohort (AUC 0.78;
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Preservation of anticorrelated brain networks predicts recovery after traumatic brain injury. · full record | OpenQuestion