ArticleOral diseases2026
Tumor Vascular Area Quantification Predicts Survival Outcomes in Oral Squamous Cell Carcinoma.
Article in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
backgroundCancer cells remodel blood vessels to create a tumor-supportive environment; however, the spatial distribution of these vessels and their prognostic significance in oral squamous cell carcinoma (OSCC) remain poorly defined.
methodsWe established an open-source pipeline to quantify vascular area (VA) in both the inner tumor (InT) and invasive tumor front (ITF) regions from CD31-stained whole-slide images (discovery cohort, n = 66). The associations between VA and patient survival were assessed via univariate and multivariate analyses. Findings were validated in an independent cohort (n = 70) immunostained with CD34.
resultsVA was significantly higher in the InT region compared to the ITF (p = 0.0079). A higher VA in the ITF was independently associated with favorable overall survival (discovery: HR 0.28, 95% CI 0.11-0.73, p = 0.009; validation: HR 0.18, 95% CI 0.07-0.47, p < 0.001) and disease-free survival (discovery: HR 0.34, 95% CI 0.14-0.81, p = 0.015; validation: HR 0.25, 95% CI 0.11-0.53, p < 0.001).
conclusionOur findings provide the first evidence that high VA in the ITF is associated with a better prognosis in OSCC.
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