Evidence map›Paper›PMID 41428794›Full record

ArticleCirculation2025

A Common Ancestry-Specific Sodium Channel Variant Increases Susceptibility to Drug-Induced QTc Prolongation: Evidence From a Large Biobank.

Russell Stewart, Brandon D Lowery, Eric Farber-Eger, Yuko Wada, Dan M Roden, Quinn S Wells, Giovanni Davogustto

Abstract readLetter
In one paragraph

Article in Circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Russell StewartSchool of Medicine (R.S.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0009-0000-9229-6176
Brandon D LoweryDepartment of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-0898-6137
Eric Farber-EgerDepartment of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-0281-3796
Yuko WadaDepartment of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-8533-8040
Dan M RodenDepartment of Biomedical Informatics (D.M.R., Q.S.W.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-6302-0389
Quinn S WellsDepartment of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-3899-0313
Giovanni DavogusttoDepartment of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-2771-6466

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
NCATS NIH HHS UL1 TR002243
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

arrhythmias, cardiacgenetic variationlong QT syndromesodium channelstorsades de pointes

Identifiers

PMID41428794
PMCPMC12721645

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.