ArticleJBRA assisted reproduction2026
The influence of melatonin supplementation on in vitro culture of murine embryos from polycystic ovary syndrome experimental models.
Article in JBRA assisted reproduction, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivePolycystic ovary syndrome (PCOS) negatively impacts oocyte and embryo quality. However, melatonin supplementation in assisted reproduction may enhance oocyte and embryo quality. This study aimed to analyze the effect of melatonin supplementation in embryo culture, by assessing embryos quality and development in murine models.
methodsC57BL/6J mice strain were divided into 6 groups: PCOS; PCOS with melatonin; placebo; placebo with melatonin; controls; and controls with melatonin. Embryo classification was performed during all developmental phases. TUNEL assay analysis was carried out in blastocysts.
resultsThe melatonin supplementation showed a positive influence during cleavage and morula development for all groups. The blastocyst rate was lower in the PCOS group when compared to placebo and controls. For the TUNEL assay, placebo and control groups supplemented with melatonin had a lower number of apoptotic cells compared to their respective non-supplemented groups.
conclusionsMelatonin supplementation exerts a beneficial impact on cleavage and morula development for all groups. For PCOS, the poor blastocyst quality and high apoptosis rate emphasizes the inherent challenges associated with this condition. Melatonin potentially mitigates apoptotic events during early embryo development, suggesting its relevance as a supplementary therapeutic approach.
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