ArticlePloS one2025
Socazolimab combined with carboplatin and etoposide as first-line treatment for extensive-stage small-cell lung cancer: A cost-effectiveness analysis in China.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04878016 (A Phase III, Randomized，Double-blind Placebo-controlled Study of Carboplatin Plus Etoposide With or Without ZKAB001), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase III, Randomized，Double-blind Placebo-controlled Study of Carboplatin Plus Etoposide With or Without ZKAB001 (Anti-PD-L1 Antibody) in Patients With Untreated Extensive-stage Small Cell Lung Cancer
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe NCT04878016 trial evaluated the efficacy and safety of socazolimab in combination with carboplatin/etoposide as a first-line treatment for extensive-stage small cell lung cancer (ES-SCLC). This study aims to analyze the cost-effectiveness of this combination regimen from the perspective of the Chinese healthcare system.
methodA Markov model with three health states was constructed. The model simulated a time horizon of 10 years with a cycle length of 3 weeks. Costs and utilities were discounted at 5% annually. The primary outcomes were total costs, quality-adjusted life years (QALYs), and the incremental cost-effectiveness ratio (ICER). One-way sensitivity analysis and probabilistic sensitivity analysis were conducted to assess the robustness of the results.
resultsThe base-case analysis showed that the ICER for the socazolimab group compared to the chemotherapy-alone group was 355,316.95 yuan/QALY, which exceeds three times China's per capita GDP in 2024 as the willingness-to-pay (WTP) threshold. One-way sensitivity analysis revealed that PD utility, PFS utility, socazolimab cost, and neutropenia management cost had significant impacts on model results. Probabilistic sensitivity analysis indicated that the probability of socazolimab combined with chemotherapy being cost-effective was 21.9%.
conclusionAt China's WTP threshold, socazolimab combined with chemotherapy is not cost-effective versus chemotherapy alone for ES-SCLC.
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