Evidence map›Paper›PMID 41428640›Full record

ReviewJournal of the science of food and agriculture2026

Efficacy of omega-3 fatty acids as a functional food: a multifaceted approach to health reinforcement.

Md Faruque Ahmad, Abdulrahman A Alsayegh, Anjum Khanam, Awais Ahmed, António Raposo, Farkad Bantun, Md Zeyaullah, Ahmad O Babalghith, Abdullah F Aldairi, Boshra Mozaffar and 3 more

Abstract readReview
In one paragraph

Review in Journal of the science of food and agriculture, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Enhanced DHA Production inMarine drugs · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Md Faruque AhmadDepartment of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Abdulrahman A AlsayeghDepartment of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Anjum KhanamDepartment of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Awais AhmedDepartment of Management, Shri JJT University, Rajasthan, India.
António RaposoCBIOS (Research Center for Biosciences and Health Technologies), ECTS (School of Health Sciences and Technologies), Lusófona University, Lisbon, Portugal.
Farkad BantunDepartment of Microbiology and Parasitology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Md ZeyaullahDepartment of Basic Medical Science, College of Applied Medical Sciences, Khamis Mushayt Campus, King Khalid University (KKU), Abha, Saudi Arabia.
Ahmad O BabalghithDepartment of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Abdullah F AldairiDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Boshra MozaffarDepartment of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Mohammed F BajahzerDepartment of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Mohamed H AbdelrahmanDepartment of Medical Laboratory Technology, Faculty of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Mohammad Intakhab AlamDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.

Funding

The Deanship of Graduate Studies and Scientific Research, Jazan University, Saudi Arabia, has financially supported through project number: RG24-S090 to carry out this study.
6 · The paper itself

Abstract

Omega-3 fatty acids (omega-3s) are polyunsaturated fatty acids linked with numerous health benefits. Omega-3s exhibit multifaceted activities through various mechanisms. Eicosapentaenoic acid (EPA) alleviates oxidative stress by lowering reactive oxygen species and improving oxidative stress in brain tissues and acts against neurodegenerative disorders. It has the potential to regulate cell membranes, decrease inflammation, improve endothelial activities, reduce triglycerides (TGs), weaken oxidative stress, and encourage cardiovascular, metabolic and immunological health. Docosahexaenoic acid (DHA) modulates mitochondrial activity, enhances mitochondrial biogenesis and facilitates fatty acid oxidation, which lowers lipid accumulation and helps energy metabolism and is effective in obesity. Omega-3s such as EPA, DHA and alpha-linolenic acid show anticancer activity, promote apoptosis, decrease the proliferation of cancer cell and enhance chemotherapy efficacy. Moreover, DHA has potential effects during pregnancy and fetal development. Omega-3s are often inadequate in our diet and play a significant therapeutic function in several disorders. They have been documented by global health specialists as essential constituents of the human diet. Their relevance depends on their ability to act as a nutritional intervention with significant uses in health promotion. Consequently, dietary nutrition is associated with disease prevention and enhanced clinical results. The growing demand for health-related products and innovations is expected to have an impact on developing dietary patterns. As a result, omega-3s are increasingly incorporated into functional foods and supplements. This analysis highlights omega-3s ability to improve health outcomes as well as prevent chronic diseases. © 2025 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Indexed as

Fatty Acids, Omega-3Functional FoodAnimalsDietary SupplementsHumansOxidative StressFatty Acids, Omega-3bioavailabilitycancercardiovascular disordersfunctional foodsomega‐3spregnancy

Identifiers

PMID41428640
PMCPMC13157248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.