Evidence map›Paper›PMID 41428500›Full record

ArticleNucleic acids research2026

ARKbase: Antimicrobial Resistance Knowledgebase1.0.

Simran Gambhir, Shweta Pandey, Harsh Bajetha, Jasleen Kaur, Ankita Das, Gnanasekar Pranavathiyani, Rupali Aggarwal, Upasana Maity, Suhani Dange, Vipin Singh and 5 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Simran GambhirBioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.ORCID 0009-0005-9270-4113
Shweta PandeyBioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.ORCID 0009-0008-8613-980X
Harsh BajethaBioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.ORCID 0009-0000-2163-9725
Jasleen KaurBioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.ORCID 0009-0001-3000-0461
Ankita DasBioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.ORCID 0009-0007-7510-8787
Gnanasekar PranavathiyaniBioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.ORCID 0000-0003-4854-8238
Rupali AggarwalBioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.ORCID 0009-0003-1306-8995
Upasana MaityBioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.ORCID 0009-0001-5727-6070
Suhani DangeBioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.ORCID 0009-0001-0497-1811
Vipin SinghIndependent Researcher, IMTECH Housing, Sector 39A, Chandigarh 160036, India.ORCID 0000-0002-4792-4409
Mayur ZarkarBioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.ORCID 0009-0004-3323-568X
Raghav SankhdherBioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.ORCID 0009-0001-2031-7158
Bhupender SinghBioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.ORCID 0000-0003-1654-5382
Shivani SethBioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.ORCID 0009-0002-5810-1712
Anshu BhardwajBioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.ORCID 0000-0001-5830-2616

Funding

Council of Scientific and Industrial Research (India) HCP-0101Council of Scientific and Industrial Research (India) HCP-047Council of Scientific and Industrial Research (India) OLP0172CSIR 31/0050(22042)/2025-EMR-ICSIR GATE31/0050(13092)/2022-EMR-IIndian Council of Medical Research IIRP-2023-2784Indian National Academy of Engineering 2023/DGRI/Cat-1/03National Research Foundation SPG/2021/004761
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) is one of the most pressing global health challenges, often referred to as a 'silent pandemic.' Towards this, ARKbase is developed as an integrated, curated, value-added knowledgebase for AMR, with focus on WHO Bacterial Priority Pathogens. ARKbase has three core modules namely-Database, Insight, and Comparative Analysis Module-each offering curated data, including data analysed with custom-built pipelines. The Database Module has curated reference genomes and pan genomes along with antimicrobial susceptibility testing (AST) profiles. The Insight Module has 14 sub-modules and offers deep annotations encompassing antimicrobial resistance genes, virulence factors, structure annotation, host-pathogen interactions, biosynthetic gene clusters, known antibiotics, protein-protein interactions, drug targets, co-targets, drug-target interactions, machine learning models, and curated transcriptomic datasets for antibiotic exposure. The Comparative Analysis module offers a simple interface for comparing antimicrobial resistance genes, virulence factors, and drug targets among different priority pathogens. The data included in ARKbase are quality-checked and curated as per CLSI standards for AST, EUCAST guidelines for genome sequence, and the FAIR data principles. ARKbase is the first comprehensive knowledgebase focusing on WHO priority pathogens and AWaRe classification, enabling a combined evidence approach towards a holistic understanding of AMR. Available at https://datascience.imtech.res.in/anshu/arkbase.

Indexed as

BacteriaDatabases, GeneticDrug Resistance, BacterialKnowledge BasesAnti-Bacterial AgentsGenome, BacterialHost-Pathogen InteractionsHumansMicrobial Sensitivity TestsMolecular Sequence AnnotationSoftwareVirulence FactorsAnti-Bacterial AgentsVirulence Factors

Identifiers

PMID41428500
PMCPMC12807638

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.