Evidence map›Paper›PMID 41428484›Full record

ArticleCell reports2026

Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through apoptosis in the neonatal lung.

Melinda E Snitow, Sylvia N Michki, Fatima N Chaudhry, Youbin Park, Rachna Dherwani, Jeremy B Katzen, David B Frank, Jarod A Zepp

Abstract read
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Melinda E SnitowDivision of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Sylvia N MichkiDivision of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Fatima N ChaudhryDivision of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Youbin ParkDivision of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Rachna DherwaniDivision of Pulmonary, Allergy, and Critical Care, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Jeremy B KatzenDivision of Pulmonary, Allergy, and Critical Care, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
David B FrankDivision of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jarod A ZeppDivision of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: zeppj@chop.edu.

Funding

Lung repair mechanisms mediated by the immune-fibroblast interfaceR35GM146835 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI Jarod Zepp · 2022 to 2026
$2.2M
Deciphering the Molecular Mechanism of Pediatric Interstitial Lung Disease to Advance Targeted TherapiesR01HL176680 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Jeremy Binder Katzen · 2025 to 2026
$1.2M
Origins of neonatal lung myofibroblastsR01HL180443 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Jarod Zepp · 2025 to 2026
$1.2M
Understanding how alveolar epithelial cell stress drives aberrant repair in interstitial lung diseaseK08HL150226 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KATZEN, JEREMY BINDER · 2020 to 2024
$840k
Defining the molecular determinants of mesenchymal lineage allocation in lung development and diseaseR00HL141684 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI ZEPP, JAROD · 2020 to 2022
$747k
CXCL12 signaling axis in pulmonary arterial heterogeneity, development, and diseaseR56HL167937 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI FRANK, DAVID BRIAN · 2023 to 2023
$657k
NHLBI NIH HHS K08 HL150226NHLBI NIH HHS R00 HL141684NHLBI NIH HHS R01 HL176680NHLBI NIH HHS R01 HL180443NHLBI NIH HHS R56 HL167937NIGMS NIH HHS R35 GM146835
6 · The paper itself

Abstract

Lung myofibroblasts are necessary for early postnatal alveolar growth. The unique contributions of individual myofibroblast lineages to alveolar development are unresolved by existing genetic tools. We generated a Stanniocalcin-1 (Stc1)

Indexed as

ApoptosisCell LineageGlycoproteinsLungMyofibroblastsAnimalsAnimals, Newbornbcl-2-Associated X Proteinbcl-2 Homologous Antagonist-Killer ProteinCell DifferentiationMiceBak1 protein, mousebcl-2-Associated X Proteinbcl-2 Homologous Antagonist-Killer ProteinGlycoproteinsteleocalcinalveologenesisapoptosisCP: developmental biologyfibroblastlung developmentmyofibroblast

Identifiers

PMID41428484
PMCPMC12976561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.