Evidence map›Paper›PMID 41428383›Full record

ArticleAmerican journal of physiology. Renal physiology2026

Dynamic and differential renal cortical cell-specific mitochondrial metabolism in response to fasting.

Kyle Feola, Andrea Henning Venable, Mina Rasouli, Julie Do, Tatyana McCoy, Claire B Llamas, Dana Straus, Joshua C Russell, Prashant Mishra, Behzad Najafian and 1 more

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Kyle FeolaDepartment of Internal Medicine (Nephrology), University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Andrea Henning VenableDepartment of Internal Medicine (Nephrology), University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Mina RasouliDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Julie DoDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Tatyana McCoyDepartment of Internal Medicine (Nephrology), University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Claire B LlamasChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Dana StrausDepartment of Laboratory Medicine & Pathology, University of Washington, Seattle, Washington, United States.
Joshua C RussellDepartment of Laboratory Medicine & Pathology, University of Washington, Seattle, Washington, United States.
Prashant MishraChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Behzad NajafianDepartment of Laboratory Medicine & Pathology, University of Washington, Seattle, Washington, United States.
Sarah C HuenDepartment of Internal Medicine (Nephrology), University of Texas Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0001-6420-2400

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
RENAL CONTROL OF BODY COMPOSITION AND BLOOD PRESSURET32DK007257 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BAUM, MICHEL GERARD, MOE, ORSON W · 1986 to 2021
$5.0M
Engineering faithful animal models of mitochondrial diseaseDP2ES030449 · NIEHS · UT SOUTHWESTERN MEDICAL CENTER · PI MISHRA, PRASHANT · 2018 to 2018
$2.4M
Harnessing Fasting Metabolism to Improve Survival in Bacterial SepsisR35GM137984 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI HUEN, SARAH · 2020 to 2024
$2.2M
Defining intra-renal ketone metabolism in kidney health and diseaseR01DK135555 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI sarah huen · 2024 to 2026
$1.8M
Deciphering the role of amino acid transporters in mitochondrial myopathyR01AR073217 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI MISHRA, PRASHANT · 2018 to 2022
$1.8M
Mechanisms of Mitochondrial Metabolic Dysfunction in Chronic Kidney DiseaseR56DK134582 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI HUEN, SARAH · 2023 to 2023
$150k
Cancer Prevention Research Institute of Texas RP240494Department of Laboratory Medicine; Pathology, University of WashingtonHHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR073217HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) P30DK017047HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK135555HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R56DK134582HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) T32DK007257HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM137984HHS | NIH | NIH Office of the Director (OD) DP2ES030449Moody Medical Research InstituteNIAMS NIH HHS R01 AR073217NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK135555NIDDK NIH HHS R56 DK134582NIDDK NIH HHS T32 DK007257NIEHS NIH HHS DP2 ES030449NIGMS NIH HHS R35 GM137984
6 · The paper itself

Abstract

The metabolic health of the kidney is directly correlated to the risk of progressive kidney disease. Our understanding of the metabolic processes that fuel the diverse functions of the kidney is limited by the kidney's structural and functional heterogeneity, especially in key metabolic organelles such as the mitochondria. As the kidney contains many different cell types, we sought to determine the intrarenal mitochondrial heterogeneity that contributes to cell-specific metabolism. To interrogate this, we used a recently developed mitochondrial tagging technique, MITO-Tag, to isolate kidney cell-type-specific mitochondria. Here, we investigated mitochondrial functional capacities and the metabolomes of the early and late proximal tubule (PT) and the distal convoluted tubule (DCT). The conditional MITO-Tag transgene was combined with

Indexed as

Energy MetabolismFastingKidney CortexKidney Tubules, DistalKidney Tubules, ProximalMitochondriaAnimalsFatty AcidsMaleMetabolomicsMiceMice, Inbred C57BLMice, TransgenicOxidation-ReductionFatty Acidscellular metabolic heterogeneitykidneymetabolismmitochondriatubular epithelium

Identifiers

PMID41428383
PMCPMC12857851

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.