Evidence map›Paper›PMID 41428259›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2025

Rare and common variants in ERAP1 and ERAP2 selected for in response to Yersinia pestis infection contribute to autoimmune disease including inflammatory bowel disease.

Lynn K Win, Guo Cheng, James J Ashton, Alex Z Kadhim, Zachary Green, R Mark Beattie, Sarah Ennis

Abstract read
In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lynn K WinHuman Development and Health, Faculty of Medicine, University Hospital Southampton, Southampton, Hampshire, SO16 6YD, UK. l.k.win@soton.ac.uk.ORCID 0000-0002-2624-0390
Guo ChengHuman Development and Health, Faculty of Medicine, University Hospital Southampton, Southampton, Hampshire, SO16 6YD, UK.
James J AshtonHuman Development and Health, Faculty of Medicine, University Hospital Southampton, Southampton, Hampshire, SO16 6YD, UK.
Alex Z KadhimHuman Development and Health, Faculty of Medicine, University Hospital Southampton, Southampton, Hampshire, SO16 6YD, UK.
Zachary GreenHuman Development and Health, Faculty of Medicine, University Hospital Southampton, Southampton, Hampshire, SO16 6YD, UK.
R Mark BeattieDepartment of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.
Sarah EnnisHuman Development and Health, Faculty of Medicine, University Hospital Southampton, Southampton, Hampshire, SO16 6YD, UK.

Funding

EPSRC funding on AI health research (EP/Y01720X/1)Wellcome Trust
6 · The paper itself

Abstract

Endoplasmic reticulum aminopeptidases (ERAP) facilitate antigen presentation. Variation in ERAP1 and ERAP2 genes underwent selection during the Black Death and impact autoimmune disease susceptibility. We assess the burden of functionally impactful variants present in ERAP1 and ERAP2 in 2 cohorts of patients diagnosed with inflammatory bowel disease (IBD; Crohn's disease (CD) or ulcerative colitis (UC)). We analysed the Southampton Genetics of IBD cohort comprising patients diagnosed with IBD, with exome and clinical data on autoimmune comorbidities (n

Indexed as

AminopeptidasesAutoimmune DiseasesInflammatory Bowel DiseasesMinor Histocompatibility AntigensColitis, UlcerativeCrohn DiseaseFemaleGene FrequencyGenetic Predisposition to DiseaseHaplotypesHumansMalePolymorphism, Single NucleotideAminopeptidasesERAP1 protein, humanERAP2 protein, humanMinor Histocompatibility AntigensAutoimmune comorbidityEndoplasmic reticulum aminopeptidase (ERAP)GenePyGeneticsInflammatory bowel disease

Identifiers

PMID41428259
PMCPMC12722269

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.