Evidence map›Paper›PMID 41428256›Full record

ArticlePflugers Archiv : European journal of physiology2025

Impact of dietary composition on behavioural expression and gut microbiome dynamics in zebrafish.

Dhanusha Sivarajan, Vidya Pothayi, Sebastian Chempakassery Devasia, Binu Ramachandran

Abstract read
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In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dhanusha SivarajanNeuronal Plasticity Group, Department of Zoology, University of Calicut, Thenhipalam, Malappuram, 673635, Kerala, India.
Vidya PothayiDivision of Molecular Biology, Department of Zoology, University of Calicut, Malappuram, Kerala, India.
Sebastian Chempakassery DevasiaDivision of Molecular Biology, Department of Zoology, University of Calicut, Malappuram, Kerala, India.
Binu RamachandranNeuronal Plasticity Group, Department of Zoology, University of Calicut, Thenhipalam, Malappuram, 673635, Kerala, India. binuramachandran@uoc.ac.in.

Funding

DST-SERB, India (ECR/2018/002479)University Grants Commission CSIR-UGC-JRF-905/2018
6 · The paper itself

Abstract

Diet is a key physiological factor shaping brain function and gut microbiota, which together form the dynamic gut-brain axis. This bidirectional communication system plays a pivotal role in regulating behavioural outcomes. Therefore, it is worth investigating various behavioural aspects and connecting them with gut microbial dynamics shaped by differential dietary composition. Using zebrafish, we examined the effects of monotypic and combined diets of live feed and commercial feed on behavioural outcomes, morphometry, and gut microbiota. After chronic dietary intervention, fish receiving a mixed diet (Artemia, pellet, and spirulina) showed behavioural profile with enhanced exploration, reduced anxiety-like behaviour, and moderate aggression, alongside a balanced gut microbial composition. In contrast, monotypic diets produced distinct effects: Artemia-only fish displayed reduced boldness, heightened anxiety, and pathogenic microbial enrichment, while pellet-only fish showed greater growth but increased aggression. These findings highlight the importance of mixed feeding regimens for maintaining healthy gut-brain-behaviour interactions and support zebrafish as a model for studying diet-microbiota-behaviour relationships.

Indexed as

Animal FeedBehavior, AnimalDietGastrointestinal MicrobiomeZebrafishAggressionAnimalsBrainAggressionAnxietyBalanced dietBehaviourExplorationGut microbiotaZebrafish

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.