Evidence map›Paper›PMID 41428238›Full record

ArticleInflammatory bowel diseases2026

Disease Outcomes After Segmental Resection of Colonic Crohn's Disease: A Retrospective Multicenter Study.

George Salem, Christopher A Bouvette, Cristian Hernandez-Rocha, Oscar Hernandez Dominguez, James Conner, Mark Silverberg, Benjamin L Cohen, Stefan Holubar, Mark Lazarev

Abstract readMulticenter Study
In one paragraph

Article in Inflammatory bowel diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

George SalemSection of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, United States.
Christopher A BouvetteSection of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, United States.ORCID 0000-0003-3870-7469
Cristian Hernandez-RochaZane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5T 3L9, Canada.
Oscar Hernandez DominguezDepartment of Gastroenterology, Faculty of Medicine, Pontificia Universidad Católica of Chile, 8380453 Santiago, Chile.
James ConnerZane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5T 3L9, Canada.
Mark SilverbergZane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5T 3L9, Canada.
Benjamin L CohenDigestive Diseases Institute, Cleveland Clinic Medical Center, Cleveland, OH 44195, United States.
Stefan HolubarDepartment of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, United States.ORCID 0000-0002-2549-9042
Mark LazarevDivision of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.

Funding

Impact of Genetic Variability on Cellular Pathways and Host-Microbiome InteractioU01DK062423 · NIDDK · SINAI HEALTH SYSTEM · PI MARK S. SILVERBERG · 2002 to 2026
$7.5M
NIDDK NIH HHS U01 DK062423
6 · The paper itself

Abstract

backgroundColonic surgery for Crohn's disease (CD) frequently involves sparing uninvolved segments of the colon. Few studies have assessed recurrence rates after segmental colectomy (SC). The aim of this study was to determine the rate of and identify the risk factors for postoperative CD recurrence.

methodsThis was a multicenter retrospective study from 3 tertiary inflammatory bowel disease (IBD) referral centers of CD patients who underwent SC between 2000 and 2019. We defined endoscopic recurrence as the presence of ulcers in the remaining colon upon postoperative colonoscopy.

resultsA total of 108 patients were included. Sixty-nine (63.9%) patients had evidence of postoperative CD endoscopic recurrence. Age at surgery <40 years and disease duration ≤156 months predicted an increased likelihood for postoperative recurrence (odds ratio [OR], 2.43; P = .031 and OR, 3.29; P = .005, respectively), whereas abdominal perineal resection (OR, 0.21; P = .005), indication for SC of malignancy (OR, 0.14; P = .016), and postoperative use of tumor necrosis factor α (TNFα) inhibitor for prophylactic purposes (OR, 0.38; P = .040) negatively predicted disease recurrence. Disease duration ≤156 months (OR, 2.86; P = .039) and postoperative TNFα inhibitor prophylaxis remained significant (OR, 0.26; P = .013) upon multivariable modeling.

conclusionAlthough high rates of recurrence persist within the postoperative phase of SC for CD, the postoperative use of TNFα inhibitor for prophylactic purposes for a subset of patients may promote a more durable endoscopic remission.

Indexed as

ColectomyCrohn DiseaseAdultColonColonoscopyFemaleFollow-Up StudiesHumansMaleMiddle AgedPostoperative ComplicationsRecurrenceRetrospective StudiesRisk FactorsTreatment OutcomeYoung AdultCrohn’s diseaseinflammatory bowel diseasepostoperative IBD recurrencesegmental colectomy

Identifiers

PMID41428238
PMCPMC13383076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.