Evidence map›Paper›PMID 41428205›Full record

ReviewIntensive care medicine2026

The medical management of acute respiratory distress syndrome.

Idunn S Morris, Marcelo Amato, Elias Baedorf Kassis, Giacomo Bellani, Carolyn S Calfee, Leo Heunks, Carol Hodgson, Priya Nair, Ary Serpa Neto, Sarina Sahetya and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Intensive care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Idunn S MorrisNepean Clinical School, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Camperdown, Australia.
Marcelo AmatoLaboratório de Pneumologia LIM-09, Faculdade de Medicina, Universidade de Sao Paulo, Hospital das Clinicas HCFMUSP, Sao Paulo, Brazil.
Elias Baedorf KassisDepartment of Anesthesia and Department of Medicine Boston, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Giacomo BellaniDepartment of Anesthesia and Intensive Care, Santa Chiara Hospital, APSS Trento., Centre for Medical Sciences CISMed, University of Trento, Trento, Italy.
Carolyn S CalfeeDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Departments of Medicine and Anesthesia, University of California, San Francisco, San Francisco, USA.
Leo HeunksDepartment of Intensive Care, Radboud University Medical Center, Nijmegen, The Netherlands.
Carol HodgsonAustralian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.
Priya NairIntensive Care Unit, St Vincent's Hospital, Sydney, Australia.
Ary Serpa NetoAustralian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Sarina SahetyaDivision of Pulmonary and Critical Care, Department of Medicine, Johns Hopkins University, Baltimore, USA.
Charlotte SummersVictor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.
Irene TeliasInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
Takeshi YoshidaDepartment of Anesthesiology and Intensive Care Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Arthur S SlutskyInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
Niall D FergusonDepartment of Physiology, University of Toronto, Toronto General Hospital, Toronto, Canada. Niall.ferguson@uhn.ca.ORCID 0000-0002-6213-5264

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite advancements in bedside monitoring and paradigm shifts in standard ventilatory practice, mortality from acute respiratory distress syndrome (ARDS) remains high. The recent Global ARDS definition adopts a more pragmatic approach enabling earlier identification across a broader patient spectrum, independent of the interventions being administered. Meanwhile, our understanding of managing this heterogeneous syndrome has shifted towards defining precise subgroups with shared therapeutic targets. Physiological, biological, and radiological phenotypes may modify the response to interventions previously showing indeterminate benefit, making them potentially central to future personalised ARDS management. This narrative review summarises core evidence for the medical and ventilatory management of ARDS, explores emerging concepts, and offers clinicians a framework for current best practice and a roadmap for possible future directions.

Indexed as

Respiration, ArtificialRespiratory Distress SyndromeHumansAcute hypoxemic respiratory failureMechanical ventilationPositive end-expiratory pressureVentilator-induced lung injury

Identifiers

PMID41428205

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.