Evidence map›Paper›PMID 41428147›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2026

Profiling of macroelements and microelements in colorectal cancer patients and their clinicopathological characteristics.

Gihani Vidanapathirana, Jun Yu Woon, Fentaw Tadese Berhe, Md Sajedul Islam, Neda Moetamedirad, Md Nurujjaman, Zhuo Chen, Cu Tai Lu, Sujani Kodagoda Gamage, Alfred K Lam and 1 more

Abstract read
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Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gihani VidanapathiranaSchool of Medicine and Dentistry, Griffith University, Gold Coast Campus, Southport, Gold Coast, QLD, 4222, Australia.
Jun Yu WoonSchool of Medicine and Dentistry, Griffith University, Gold Coast Campus, Southport, Gold Coast, QLD, 4222, Australia.
Fentaw Tadese BerheSchool of Medicine and Dentistry, Griffith University, Gold Coast Campus, Southport, Gold Coast, QLD, 4222, Australia.
Md Sajedul IslamSchool of Medicine and Dentistry, Griffith University, Gold Coast Campus, Southport, Gold Coast, QLD, 4222, Australia.
Neda MoetamediradSchool of Medicine and Dentistry, Griffith University, Gold Coast Campus, Southport, Gold Coast, QLD, 4222, Australia.
Md NurujjamanSchool of Medicine and Dentistry, Griffith University, Gold Coast Campus, Southport, Gold Coast, QLD, 4222, Australia.
Zhuo ChenSchool of Medicine and Dentistry, Griffith University, Gold Coast Campus, Southport, Gold Coast, QLD, 4222, Australia.
Cu Tai LuSchool of Medicine and Dentistry, Griffith University, Gold Coast Campus, Southport, Gold Coast, QLD, 4222, Australia.
Sujani Kodagoda GamageSchool of Medicine and Dentistry, Griffith University, Gold Coast Campus, Southport, Gold Coast, QLD, 4222, Australia.
Alfred K LamSchool of Medicine and Dentistry, Griffith University, Gold Coast Campus, Southport, Gold Coast, QLD, 4222, Australia. a.lam@griffith.edu.au.
Vinod GopalanSchool of Medicine and Dentistry, Griffith University, Gold Coast Campus, Southport, Gold Coast, QLD, 4222, Australia. v.gopalan@griffith.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macroelements and microelements/ trace elements are vital for human physiological processes. Alterations in these elements have been linked to various pathological conditions, including colorectal cancer (CRC), a significant cause of cancer-related mortality. This study investigated the concentrations of macroelements and microelements across different stages of CRC and compared them with non-neoplastic colon tissues. Additionally, four toxic elements (Hg, As, Cd, and Pb) were analysed in these tissues. Sixty tissue samples were prospectively collected from patients undergoing CRC resections and large bowel mucosal tissue samples without tumour (n=10) were also collected. The concentrations of 21 elements, including macro and microelements, were quantified using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). Data analysis was performed using RStudio and SPSS software version 30. Significant differences in the concentrations of K, Mg, P, Si, Fe, Mn, Cu, Cr, and Co were observed across different colorectal cancer and non-neoplastic tissues. Heavy metals such as Hg, Cd, and As were undetectable in all tissues, except for one control sample containing 2.44 µg/g of Pb. The Cu/Zn ratio was significantly lower in advanced CRC (stages III-IV) compared to early stages (I-II). Fe, Mn, Cu, Zn, Si, Cr, P, and Co concentrations were significantly associated with CRC stages. Fe levels are also associated with metastasis and tumour site. Tumour size was linked to Na, K, and Mg, while disease spread (localised vs. advanced) was associated with K, Mn, Zn, Si, Cr, and P. These findings highlight dynamic alterations in element concentrations across different stages of CRC. This elemental profiling could form the basis of future research into stage-specific biomarkers or prognostic indicators in CRC.

Indexed as

Colorectal NeoplasmsTrace ElementsAdultAgedFemaleHumansMaleMiddle AgedTrace ElementsColorectal cancerElemental profilingMacroelementsMicroelementsPrognostic biomarkersTrace elementsTumour stages

Identifiers

PMID41428147

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.