Evidence map›Paper›PMID 41428142›Full record

ArticleOdontology2026

miR-135b-5p modulates the progression and clinical outcomes of oral squamous cell carcinoma through the negative regulation of TXNIP.

Ya Gao, Yi Lu, Kun Cao

Abstract read
PubMed Publisher
In one paragraph

Article in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ya Gao *Jiangnan University Medical Center, Wuxi, China.
Yi Lu *Department of Stomatology, Baoying Traditional Chinese Medicine Hospital, Yangzhou, 225800, China.
Kun CaoStomatology Department, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China, 221006, No.99, Huaihai West Road, Quanshan District. kuncaodr@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the oral cavity with a poor prognosis. Purpose This study aimed to investigate the expression, biological functions, and clinical significance of miR-135b-5p in OSCC. Methods Bioinformatic analysis was used to predict targets of miR-135b-5p, and a dual-luciferase reporter assay verified the targeting relationship with TXNIP. In OSCC cell lines, cell proliferation and migration were assessed using CCK-8 and Transwell assays, respectively; oxidative damage and ferroptosis were evaluated by detecting intracellular levels of Fe

Indexed as

Carcinoma, Squamous CellCarrier ProteinsMicroRNAsMouth NeoplasmsCell Line, TumorCell MovementCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedOxidative StressPrognosisCarrier ProteinsMicroRNAsMIRN135 microRNA, humanTXNIP protein, humanFerroptosismiR-135b-5pOxidative damageSquamous cell carcinoma of the oral mucosaTumor progressionTXNIP

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.