Evidence map›Paper›PMID 41428071›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2025

Using endocrine profiles to explore subgroups among transdiagnostic neurodiverse children and adolescents.

Kelly Mo, Jane Foster, Shane R Cleary, Evdokia Anagnostou, Jason P Lerch, Hsiang-Yuan Lin, Margot J Taylor, Peter Szatmari, Jennifer Crosbie, Russell Schachar and 7 more

Erratum issuedAbstract read
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In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Kelly MoInstitute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Jane FosterDepartment of Psychiatry, Center for Depression Research and Clinical Care, O'Donnel Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA.
Shane R ClearyDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Evdokia AnagnostouInstitute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Jason P LerchMouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Hsiang-Yuan LinInstitute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Margot J TaylorNeurosciences and Mental Health Programme, The Hospital for Sick Children, Toronto, ON, Canada.
Peter SzatmariDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Jennifer CrosbieDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Russell SchacharNeurosciences and Mental Health Programme, The Hospital for Sick Children, Toronto, ON, Canada.
Robert NicolsonDepartment of Psychiatry, University of Western Ontario, London, ON, Canada.
Stelios GeorgiadisDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Elizabeth KelleyDepartment of Psychology, Queen's University, Kingston, ON, Canada.
Jessica JonesDepartment of Psychiatry, Queen's University, Kingston, ON, Canada.
Jessica BrianBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
Mark R PalmertInstitute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Meng-Chuan LaiInstitute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. mengchuan.lai@utoronto.ca.ORCID http://orcid.org/0000-0002-9593-5508

Funding

Institute of Gender and Health GSB 171373
6 · The paper itself

Abstract

There is considerable heterogeneity in neurodevelopmental disorders (NDDs) that complicates research and clinical support. Although the biological mechanisms of NDDs remain uncertain, emerging studies suggest potential roles of hormone pathways as gonadal, thyroid, glucocorticoid and growth hormones all contribute to brain development. Alterations to these pathways and imbalances of hormones may modulate neural and behavioural development and contribute to the biology of NDDs. Importantly, the field lacks transdiagnostic investigations of endocrine-related phenotypic characteristics. The present study takes a data-driven, transdiagnostic approach to identify and characterize NDD subgroups with distinct endocrine profiles and explores their differences in behavioural phenotypes. We explored the roles of key endocrine analytes spanning specific hormonal systems including the hypothalamic-pituitary-adrenal, hypothalamic-pituitary-gonadal, as well as growth and metabolic axes. Bio-banked serum samples of 186 young people with and without NDDs, aged 3-19 years, were analyzed. Age- and sex-adjusted z-scores were generated for hormone measurements. After dimensionality reduction using robust principal component analysis, k-means clustering generated three diagnosis-agnostic groups with different sex composition, endocrine profiles, and behavioural associations related to externalizing behaviours and adaptive functioning. This exploratory study highlights the potential for endocrine profiles as stratification markers in identifying biologically homogenous subgroups across individuals with and without NDDs.

Indexed as

ADHDAutismChildren and adolescentsEndocrineHormoneNeurodevelopmental disordersSubgrouping

Identifiers

PMID41428071

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.