Evidence map›Paper›PMID 41427895›Full record

ArticleJournal of medicinal chemistry2026

1-Hydroxy-1,8-napthyridinone (DHN) Analogs Potently Inhibit Monkeypox Virus Resolvase (Mpr).

Samuel Offei, Jacob P Mahoney, Ziyue Wang, Anil Pant, Won Hee Ryu, Roshan Katekar, Jiashu Xie, Zhilong Yang, Zhengqiang Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samuel OffeiCenter for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Jacob P MahoneyCenter for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0002-7174-9161
Ziyue WangDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas 77843, United States.
Anil PantDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas 77843, United States.
Won Hee RyuCenter for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Roshan KatekarCenter for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Jiashu XieCenter for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0002-6148-5203
Zhilong YangDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas 77843, United States.
Zhengqiang WangCenter for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0002-1326-5986

Funding

Development of novel antivirals against mpox (monkeypox) virusR01AI183580 · NIAID · UNIVERSITY OF MINNESOTA · PI Zhengqiang Wang, Zhilong Yang · 2024 to 2026
$2.3M
NIAID NIH HHS R01 AI183580
6 · The paper itself

Abstract

The virally encoded Holliday junction resolvase is required for poxvirus genome replication and viral maturation. Previously, a 1-hydroxy-1,8-napthyridinone (DHN) analog (

Indexed as

Antiviral AgentsEnzyme InhibitorsMonkeypox virusAnimalsHumansStructure-Activity RelationshipVaccinia virusAntiviral AgentsEnzyme Inhibitors

Identifiers

PMID41427895
PMCPMC12796986

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.