Evidence map›Paper›PMID 41427710›Full record

ArticleJournal of virology2026

A recurrent adaptive mutation in the transmembrane 2B protein of an insect picorna-like virus in a nonnative host.

Oscar M Lezcano, Lara Fuhrmann, Reinder T Bos, Haitao Wang, Milou Stevens, Niko Beerenwinkel, Martijn A Huynen, Ronald P van Rij

Abstract read
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Oscar M Lezcano *Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0003-1748-0621
Lara Fuhrmann *Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.ORCID 0000-0001-6405-0654
Reinder T BosDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0009-0007-5535-338X
Haitao WangDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.
Milou StevensDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.
Niko BeerenwinkelDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.ORCID 0000-0002-0573-6119
Martijn A HuynenDepartment of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0001-6189-5491
Ronald P van RijDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0003-0221-4689

Funding

China Scholarship Council 202208320155Horizon 2020 European Commission (EC) 955974
6 · The paper itself

Abstract

Virus emergence is often due to cross-species transmission and adaptation to the new host. We studied the effect of innate immune responses on shaping virus populations in native and nonnative virus-host combinations, using as a model system IMPORTANCE: The forces driving virus evolution are central to understanding cross-species transmission and virus emergence. It is well established that the adaptive immune system drives virus evolution in mammals, but whether innate responses likewise drive virus evolution upon host shifts is less well understood. In this manuscript, we used

Indexed as

DicistroviridaeDrosophila melanogasterMutationPicornaviridaeViral Nonstructural ProteinsAnimalsDrosophila ProteinsImmunity, InnateMembrane ProteinsSTING ProteinDrosophila ProteinsMembrane ProteinsSTING ProteinSting protein, DrosophilaViral Nonstructural Proteinscross-species transmissionDicistroviridaeDrosophila melanogasterinsect immunityPicornaviralesRNA virusvirus evolutionvirus-host interactions

Identifiers

PMID41427710
PMCPMC12817933

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.