ArticleOrganic letters2026
Photocatalytic Aminoarylation of Styrenes.
Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
3 authors.
Funding
Abstract
Arylethylamines are privileged motifs in bioactive compounds and pharmaceuticals. Described here is a novel photocatalytic aminoarylation of styrenes to afford arylethylamines utilizing commercially available reagents. Aryl iodides undergo single-electron reduction to yield an aryl radical intermediate, enabling subsequent addition to styrenes. The resulting benzylic radical then undergoes oxidation to a carbocation and is trapped by a nucleophilic amine. Mechanistic studies, including Stern-Volmer fluorescence quenching studies and radical trapping experiments, support the proposed catalytic cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.