Evidence map›Paper›PMID 41427648›Full record

ArticleJournal of neurochemistry2025

PARP Activity Is Essential for Retinal Photoreceptor Survival in the Human Homologous Rho

Yu Zhu, Azdah Hamed A Fallatah, Kangwei Jiao, Mathias W Seeliger, François Paquet-Durand

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yu ZhuCell Death Mechanisms Group, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.ORCID 0000-0003-2727-1356
Azdah Hamed A FallatahCell Death Mechanisms Group, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.ORCID 0009-0007-2720-5021
Kangwei JiaoKey Laboratory of Yunnan Province, Yunnan Eye Institute, Affiliated Hospital of Yunnan University, Yunnan University, Kunming, Yunnan, China.ORCID 0000-0003-3202-5993
Mathias W SeeligerDivision of Ocular Neurodegeneration, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.ORCID 0000-0002-7879-6788
François Paquet-DurandCell Death Mechanisms Group, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.ORCID 0000-0001-7355-5742

Funding

Charlotte and Tistou Kerstan Foundation PD2017Key Project of Yunnan Fundamental Research Projects 202301AS070046
6 · The paper itself

Abstract

Retinitis Pigmentosa (RP) is a group of rare, inherited, neurodegenerative diseases of the retina that primarily affect rod photoreceptors. The initial loss of rods is followed by a secondary cone photoreceptor degeneration and eventually legal blindness. Despite several attempts, RP still remains essentially untreatable. In recent years, inhibition of poly (ADP-ribose) polymerase (PARP) has been proposed as a potential therapeutic strategy for autosomal-recessive RP, based on promising work in preclinical animal models. However, the effects of PARP inhibitors in autosomal-dominant RP are still largely unknown. Here, we employed a novel, human-homologous rhodopsin-mutant Rho

Indexed as

Photoreceptor Cells, VertebratePoly(ADP-ribose) PolymerasesRetinitis PigmentosaRhodopsinAnimalsCell SurvivalDisease Models, AnimalHumansMiceMice, Inbred C57BLMice, TransgenicPoly(ADP-ribose) Polymerase InhibitorsRetinal Rod Photoreceptor CellsPoly(ADP-ribose) Polymerase InhibitorsPoly(ADP-ribose) PolymerasesRhodopsinapoptosiscGMPIRDnon‐apoptotic cell deathPARthanatosRD

Identifiers

PMID41427648
PMCPMC12721004

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.