ArticleRegenerative biomaterials2025
The impact of microstructure and extracellular matrix suspension on the proliferation of bone marrow-derived mesenchymal stem cells for osteochondral defect repair.
Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Three-dimensionally-printed biphasic PCL/Regenerative biomaterials · 2026Article
- Hybrid hydrogel system integrating thermoresponsive microspheres and KGN-loaded nanofibers enables efficient cartilage matrix regeneration.Regenerative biomaterials · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteochondral defects are a challenge in orthopaedic surgery due to the complexity and function of cartilage. Within this scenario, this study aimed to develop/characterize bioactive porous supports based on oxidized polyvinyl alcohol (OxPVA), with/without human cartilage-derived decellularized ECM (dECM), as platforms for HM1-SV40 cell adhesion and proliferation. OxPVA scaffolds were fabricated using a particle-leaching technique (gelatin concentrations: 10%, 15% and 25% w/w); Scanning Electron Microscopy (SEM) was used to examine the ultrastructure, and a morphometric study assessed pores number, size and porosity percentage. Fluorescence Recovery after Photobleaching (FRAP) was used to evaluate the interconnectivity of the scaffold pores. To enhance the bioactivity of OxPVA, dECM (25% w/w) was incorporated into the scaffolds; thus, the expression of genes related to collagen synthesis and cartilage differentiation/remodelling in seeded HM1-SV40 cells was analyzed by quantitative PCR; relative protein expression levels of SOX9, ACAN and COMP were also assessed. Composite scaffolds biocompatibility was proved by subcutaneous implantation in Sprague-Dawley. As for bone, 3D-printed polylactic acid (PLA)-based scaffolds with varying geometries (67%, 53% and 40% porosity; 600-1400 µm pores size) were fabricated and tested
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.