ArticleRegenerative biomaterials2025
Hybrid nanocomposite conduit based on oxidized polyvinyl alcohol and multiwalled carbon nanotubes: a new device supporting peripheral nerve regeneration in animal model of disease.
Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Long-term exploratory evaluation of an acellular biomimetic polyfascicular nerve guidance conduit for peripheral nerve repair in a rhesus macaque model.Bioactive materials · 2027Article
- Conductive ionic liquid hydrogel filled anti-inflammatory nerve conduit repairs peripheral nerve defect.Materials today. Bio · 2026Article
- Nanotube-Assisted Motor Neuron and Neuromuscular Junction Stabilization in Spinal Muscular Atrophy: A Hypothesis for Adjunctive Therapy.Neurology international · 2026Review
- Acellular nerve perineurium repairs peripheral nerve injuries in a rat model via ECM-mediated barrier and optimization of the regenerative microenvironment.Regenerative biomaterials · 2026Article
- Advanced materials and devices strategies of mechanical stimulation for tissue regeneration.Regenerative biomaterials · 2026Review
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Authors and funding
16 authors.
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Abstract
Severe peripheral nerve injuries represent a significant clinical problem, and intense efforts are dedicated toward the identification of the 'ideal' nerve conduit (NC). In this context, incorporating electrical cues within the device wall seems to be extremely appealing. Here, a new NC based on the new polymer oxidized polyvinyl alcohol (OxPVA) (oxidation degree 1%) + water-soluble multiwalled carbon nanotubes (MWCNT-S) (0.1 wt% in OxPVA) was developed and characterized for ultrastructure and mechanical behavior. Subsequently, OxPVA+MWCNT-S NCs were implanted in animal model of disease (Sprague-Dawley rat; sciatic nerve, gap: 5 mm) and compared with OxPVA and Reverse Autograft. Following sciatic functional index evaluation, implants-associated outcomes were verified on explants through histology, immunohistochemistry, immunofluorescence and morphometric studies on semithin sections, after 6 weeks from surgery. According to preclinical study evidence, all the NCs supported nerve regeneration (S100/β-tubulin/neurofilaments) without severe inflammatory reaction (CD3/F4/80). Morphometric studies showed the highest cross-section area and fascicular area for Reverse Autograft followed by OxPVA+MWCNT-S and OxPVA. The epineurium thickness was the highest in Reverse Autograft followed by OxPVA and OxPVA+MWCNT-S. Myelinated axon density was highest for OxPVA+MWCNT-S, followed by OxPVA and Reverse Autograft; myelinated axons total number followed this descending order Reverse Autograft˃OxPVA+MWCNT-S˃OxPVA. Additionally, the g-ratio distribution highlighted a similar trend for OxPVA+MWCNT-S and Reverse Autograft with most nerve fibers within the 0.6-0.7 interval. Atrophy of the operated-limb gastrocnemius was comparable in the whole cohort. Interestingly, MWCNT-S incorporation in OxPVA showed to be an appealing strategy to improve the morpho-structural outcomes associated with these devices.
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