In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
19 authors.
Sam Barnett DubenskyMedical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-9799-8089 Molly GallagherDivision of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kingsley Gideon KumashieDivision of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0001-7713-1779 Tianyu LuDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0000-6546-0428 Jonathan TedescoDivision of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0009-0006-4637-4026 Nina De LunaImmunology Graduate Group, Biomedical Graduate Studies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-9418-9059 Katherine PremoImmunology Graduate Group, Biomedical Graduate Studies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-9214-659X Suzanna RachimiImmunology Graduate Group, Biomedical Graduate Studies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-7294-8683 Emylette Cruz CabreraDivision of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Bria FulmerImmunology Graduate Group, Biomedical Graduate Studies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0008-7158-9760 Ijeoma C MeremikwuGraduate Group in Genomics and Computational Biology, Biomedical Graduate Studies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-9704-3127 Ashley CarterDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Sarah E HenricksonDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-5569-4132 Neil RombergDivision of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-1881-5318 Amy E BaxterDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-1555-0713 Derek A OldridgeDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-2177-5633 Laura A VellaDivision of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-8917-4845 Funding
UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3MVirus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ronald G Collman · 1999 to 2026
$78.6MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007170 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BRASS, LAWRENCE F · 1985 to 2022
$54.0MTRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GARY D. WU · 1997 to 2026
$32.5MTRAINING IN HIV PATHOGENESIST32AI007632 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Frederic D Bushman, James L. Riley · 2000 to 2026
$10.6MThe molecular circuits controlling human T follicular regulatory cell developmentR01AI179680 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI NEIL DAVID ROMBERG · 2025 to 2026
$1.6MTranscriptional and epigenetic regulation of Tfh dysfunction in HIVK08AI136660 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI VELLA, LAURA A · 2018 to 2022
$778kNCI NIH HHS P30 CA016520NIAID NIH HHS K08 AI136660NIAID NIH HHS P30 AI045008NIAID NIH HHS R01 AI179680NIAID NIH HHS T32 AI007632NIDDK NIH HHS P30 DK050306NIGMS NIH HHS T32 GM007170
6 · The paper itselfAbstract
CD4 T follicular helper (Tfh) cells coordinate humoral immune responses within germinal centers (GC) of lymphoid tissue. Despite their critical roles in vaccination and autoimmunity, the gene expression programs that define functionally distinct human Tfh states- and the molecular pathways engaged by Tfh positioned within the GC niche-remain incompletely understood. This gap has limited translational efforts to monitor or therapeutically target specific Tfh states for clinical benefit. Here, we delineate human CD4 T cell heterogeneity in tonsils and peripheral blood using trimodal single-cell sequencing and spectral flow cytometry to define epigenomic, transcriptional, and proteomic features of distinct Tfh states. Tfh with a GC-like phenotype exhibited markedly increased chromatin accessibility and both mRNA and protein expression of G protein subunit gamma 4 (
Identifiers
PMID41427421
PMCPMC12713147
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