Evidence map›Paper›PMID 41427387›Full record

ArticlebioRxiv : the preprint server for biology2025

RamanOmics Decodes Spatial Vibrational-Molecular Architecture and Rewiring in Aging and Repair.

Ke Zhang, Xingjian Chen, Francesco Monticolo, Salvatore Sorrentino, Haochun Huang, Claire Callahan, Yueqing Qiao, Judy Zhou, Sonia Brodowska, Styliani Sapantzi and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Ke ZhangCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Xingjian ChenCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Francesco MonticoloCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Salvatore SorrentinoCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Haochun HuangCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Claire CallahanCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yueqing QiaoCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Judy ZhouCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Sonia BrodowskaCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Styliani SapantziCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jianhuan QiCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yinghan WuCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Thai Nam Son DangCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Francesca ViggianiCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Chia-Kang HoKrantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Yanxin XuKrantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Koseki J Kobayashi-KirschvinkLaser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Thang MungCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hemali PhatnaniCenter for Genomics of Neurogenerative Disease, New York Genome Center, New York, NY, USA.
Zhixun DouKrantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Jeon Woong KangLaser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Peter T C SoLaser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jian ShuCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Funding

Data Analysis CoreU54AG076040 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHATNANI, HEMALI · 2021 to 2025
$13.1M
Wide-Field Short-Wave Infrared (SWIR) multiphoton (MP) tissue imagingP41EB015871 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2012 to 2021
$11.3M
Single-cell label-free identification of senescence by Raman microscopy and spatial genomicsUH3CA275687 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Jeon Woong Kang, Jian Shu · 2024 to 2026
$2.3M
Single-cell proteomic identification of novel markers of senescenceUH3CA268117 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI DOU, ZHIXUN, RAJAGOPAL, JAYARAJ · 2023 to 2024
$1.9M
Single-cell proteomic identification of novel markers of senescenceUG3CA268117 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI DOU, ZHIXUN, RAJAGOPAL, JAYARAJ · 2021 to 2022
$1.2M
Single-cell label-free identification of senescence by Raman microscopy and spatial genomicsUG3CA275687 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2022 to 2023
$1.1M
Molecular Imaging for diagnosis and monitoring of Otitis MediaR01DC021326 · NIDCD · STANFORD UNIVERSITY · PI VALDEZ, TULIO ALBERTO · 2024 to 2024
$726k
NCI NIH HHS UG3 CA268117NCI NIH HHS UG3 CA275687NCI NIH HHS UH3 CA268117NCI NIH HHS UH3 CA275687NIA NIH HHS U54 AG076040NIBIB NIH HHS P41 EB015871NIDCD NIH HHS R01 DC021326
6 · The paper itself

Abstract

Aging and tissue repair involve multilayered and spatially heterogeneous remodeling across transcriptional, biochemical, and cellular dimensions, yet prevailing definitions rely on isolated molecular markers that obscure how biochemical and transcriptional states co-evolve in tissues. Here we present RamanOmics, a multimodal framework that integrates single-nucleus RNA sequencing (snRNA-seq), spatial transcriptomics, and label-free Raman imaging to map the spatial vibrational-biochemical and molecular architecture of aging and senescence directly in intact tissues. Applied to mouse lung and skin, RamanOmics generates spatially resolved biochemical-molecular maps revealing tissue-specific programs: lung senescent cells are enriched for extracellular matrix (ECM) remodeling and TGF-β signaling (

Identifiers

PMID41427387
PMCPMC12713760

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.