Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
19 authors.
Pasquale C PutterMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0002-1995-2904
Di GuanDepartment of Obstetrics and Gynaecology, Columbia University Irving Medical Centre, New York, USA.ORCID 0009-0007-8253-1137
Thies GehrmannMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0003-4666-5406
Daniel KolbeInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.ORCID 0000-0002-6607-7591
Jiping YangDepartment of Obstetrics and Gynaecology, Columbia University Irving Medical Centre, New York, USA.ORCID 0000-0001-6332-8693
HyeRim HanDepartment of Obstetrics and Gynaecology, Columbia University Irving Medical Centre, New York, USA.
Seungsoo KimDepartment of Obstetrics and Gynaecology, Columbia University Irving Medical Centre, New York, USA.ORCID 0000-0002-6602-633X
Nico LakenbergMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.
H Eka D SuchimanMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0002-7168-5516
Stella TrompetGerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0001-5006-0528
Georg C LiuMax Planck Institute for Biology of Ageing, Cologne, Germany.
Eugen BallhysaMax Planck Institute for Biology of Ageing, Cologne, Germany.ORCID 0000-0002-9715-8685
Niels M A van den BergMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0001-7169-9881
Almut NebelInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Marian BeekmanMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0003-0585-6206
Yousin SuhDepartment of Obstetrics and Gynaecology, Columbia University Irving Medical Centre, New York, USA.ORCID 0000-0002-6014-3084
P Eline SlagboomMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0002-2875-4723
Joris DeelenMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0003-4483-3701
Funding
THE IMPACT OF CELLULAR DEFENSE ON THE ROLE OF Ku80 IN GENOME MAINTENANCE AND LONGP01AG017242 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI VIJG, JAN · 1999 to 2023
$46.1M
Validation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JAN VIJG · 2017 to 2026
$24.5M
NIA NIH HHS P01 AG017242NIA NIH HHS U19 AG056278
6 · The paper itself
Abstract
Life expectancy has steadily increased in the last two centuries, while healthspan has been lagging behind. Survival into extreme ages strongly clusters within families which often exhibit a delayed onset of (multi)morbidity, yet the underlying protective genetic mechanisms are still largely undefined. We performed affected sib-pair linkage analysis in 212 sibships enriched for ancestral longevity and identified four genomic regions (LOD
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families. · full record | OpenQuestion