Evidence map›Paper›PMID 41427381›Full record

ArticlebioRxiv : the preprint server for biology2025

Hypernatremia Enhances Transient Outward Potassium and Late Sodium Currents in a Mouse Model of Long QT Syndrome Type 3.

Xiaobo Wu, Sharon A Swanger, Gregory S Hoeker, Rowan Maisonneuve, Peter Carmeliet, Robert G Gourdie, Seth H Weinberg, Steven Poelzing

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaobo WuTranslational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Roanoke, Virginia.ORCID 0000-0002-3136-5059
Sharon A SwangerCenter for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA.ORCID 0000-0003-0615-6244
Gregory S HoekerCenter for Vascular and Heart Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA.ORCID 0000-0002-3917-4791
Rowan MaisonneuveTranslational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Roanoke, Virginia.
Peter CarmelietLaboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, VIB, Leuven, 3000, Belgium.ORCID 0000-0001-7961-1821
Robert G GourdieCenter for Vascular and Heart Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA.ORCID 0000-0001-6021-0796
Seth H WeinbergDepartment of Biomedical Engineering, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-1170-0419
Steven PoelzingCenter for Vascular and Heart Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA.ORCID 0000-0002-6979-1264

Funding

PATTERNING OF GAP JUNCTION COUPLING IN DEVELOPING HEARTR01HL056728 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI GOURDIE, ROBERT G · 1997 to 2021
$5.6M
Connexin-based Signaling in the Heart: Cellular and ExosomalR35HL161237 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI ROBERT G GOURDIE · 2022 to 2026
$4.4M
Role of the Extracellular Space as a Modulator of the Cardiac Gap Junction - Conduction Velocity RelationshipR01HL102298 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN · 2011 to 2020
$3.9M
Signaling in Inherited and Acquired Sodium Channel Gain of FunctionR01HL138003 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN, WEINBERG, SETH HOWARD · 2018 to 2021
$2.6M
Therapeutic Targeting of Voltage Gated Sodium Channel AutoregulationR01HL169610 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Steven Poelzing, Seth Howard Weinberg · 2024 to 2026
$2.1M
The Role of the Sodium Channel Beta Subunit in Cardiac ConductionR01HL141855 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI GOURDIE, ROBERT G, POELZING, STEVEN · 2018 to 2021
$1.8M
NHLBI NIH HHS R01 HL056728NHLBI NIH HHS R01 HL102298NHLBI NIH HHS R01 HL138003NHLBI NIH HHS R01 HL141855NHLBI NIH HHS R01 HL169610NHLBI NIH HHS R35 HL161237
6 · The paper itself

Abstract

Cardiac voltage-gated sodium channel gain-of-function (Na Objective: Determine whether hypernatremia and perinexal expansion synergistically prolong APD in an animal model functionally expressing I Methods: Whole-cell I Results: In isolated myocytes, hypernatremia (160mM sodium) increased I Conclusions: Hypernatremia during Na

Indexed as

Basic Science ResearchCongenital Heart DiseaseElectrophysiologyTranslational Studies

Identifiers

PMID41427381
PMCPMC12713656

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.