Evidence map›Paper›PMID 41427370›Full record

ArticlebioRxiv : the preprint server for biology2025

Molecular basis of tRNA substrate recognition and modification by the atypical SPOUT methyltransferase Trm10.

Suparno Nandi, Sarah E Strassler, Debayan Dey, Aiswarya Krishnamohan, George M Harris, Lindsay R Comstock, Jane E Jackman, Graeme L Conn

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Suparno NandiDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-3534-8002
Sarah E StrasslerDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-7555-9608
Debayan DeyDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-0222-6092
Aiswarya KrishnamohanDepartment of Chemistry and Biochemistry and Center for RNA Biology, The Ohio State University, Columbus, Ohio, USA.
George M HarrisDepartment of Chemistry, Wake Forest University, Winston-Salem, North Carolina, USA.
Lindsay R ComstockDepartment of Chemistry, Wake Forest University, Winston-Salem, North Carolina, USA.ORCID 0000-0003-0764-7344
Jane E JackmanDepartment of Chemistry and Biochemistry and Center for RNA Biology, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0001-9291-8852
Graeme L ConnDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-2419-380X

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
Mechanisms and Biological functions of SPOUT methyltransferasesR01GM130135 · NIGMS · OHIO STATE UNIVERSITY · PI Jane Elizabeth Jackman · 2018 to 2026
$2.3M
NIGMS NIH HHS R01 GM130135NIGMS NIH HHS U24 GM129539
6 · The paper itself

Abstract

The evolutionarily conserved methyltransferase Trm10 modifies the N1 position of guanosine 9 (G9) in some tRNAs, but how the enzyme recognizes and modifies its substrate tRNAs remains unclear. Here, we used an S-adenosyl-L-methionine (SAM) analog to trap the Trm10-tRNA

Indexed as

methylationprotein-RNA recognitionSPOUT methyltransferasetRNA

Identifiers

PMID41427370
PMCPMC12713601

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.